Department of Physiology and Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Physiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Cell Tissue Bank. 2021 Jun;22(2):249-262. doi: 10.1007/s10561-020-09885-6. Epub 2020 Nov 24.
Cerebral ischemic injury as the main manifestation of stroke can occur in stroke patients (70-80%). Nowadays, the main therapeutic strategy used for ischemic brain injury treatment aims to achieve reperfusion, neuroprotection, and neurorecovery. Also, angiogenesis as a therapeutic approach maybe represents a promising tool to enhance the prognosis of cerebral ischemic stroke. Unfortunately, although many therapeutic approaches as a life-saving gateway for cerebral ischemic injuries like pharmacotherapy and surgical treatments are widely used, they all fail to restore or regenerate damaged neurons in the brain. So, the suitable therapeutic approach would focus on regenerating the lost cells and restore the normal function of the brain. Currently, stem cell-based regenerative medicine introduced a new paradigm approach in cerebral ischemic injuries treatment. Today, in experimental researches, different types of stem cells such as mesenchymal stem cells have been applied. Therefore, stem cell-based regenerative medicine provides the opportunity to inquire and develop a more effective and safer therapeutic approach with the capability to produce and regenerate new neurons in damaged tissues.
脑缺血性损伤是中风患者的主要表现形式（70-80%）。如今，用于治疗缺血性脑损伤的主要治疗策略旨在实现再灌注、神经保护和神经恢复。此外，血管生成作为一种治疗方法，可能是提高脑缺血性中风预后的有前途的工具。不幸的是，尽管许多治疗方法（如药物治疗和手术治疗）作为挽救生命的脑缺血损伤的途径被广泛应用，但它们都不能恢复或再生大脑中受损的神经元。因此，合适的治疗方法将集中在再生丢失的细胞并恢复大脑的正常功能上。目前，基于干细胞的再生医学为治疗脑缺血损伤带来了新的范例。如今，在实验研究中，已经应用了不同类型的干细胞，如间充质干细胞。因此，基于干细胞的再生医学为研究和开发更有效和更安全的治疗方法提供了机会，这种方法有能力在受损组织中产生和再生新的神经元。
