Faculty of Law, Oxford University, Oxford OX1 3UL, UK.
The Fragile X Society, Great Dunmow CM6 1DA, UK.
Cells. 2022 Mar 19;11(6):1044. doi: 10.3390/cells11061044.
The European Fragile X Network met in Wroclaw, Poland, November 2021, and agreed to work towards the eradication of the word "retardation" in regard to the naming of the fragile X gene (FRAXA) and protein (FMRP). There are further genes which have "retardation" or abbreviations for "retardation" in their names or full designations, including FMR1, FMR2, FXR1, FXR2, NUFIP1, AFF1, CYFIP1, etc. "Retardation" was commonly used as a term in years past, but now any reference, even in an abbreviation, is offensive. This article discusses the stigmatisation associated with "retardation", which leads to discrimination; the inaccuracy of using "retardation" in these designations; and the breadth of fragile X syndrome being beyond that of neurodiversity. A more inclusive terminology is called for, one which ceases to use any reference to "retardation". Precedents for offensive gene names being altered is set out. The proposal is to approach the HGNC (HUGO [Human Genome Organisation] Gene Nomenclature Committee) for new terminology to be enacted. Ideas from other researchers in the field are welcomed.
欧洲脆性 X 网络于 2021 年 11 月在波兰弗罗茨瓦夫举行会议,会上一致同意努力消除脆性 X 基因(FRAXA)和蛋白(FMRP)命名中“智力迟钝”一词。还有其他一些基因的名称或全称中带有“智力迟钝”或其缩写,包括 FMR1、FMR2、FXR1、FXR2、NUFIP1、AFF1、CYFIP1 等。“智力迟钝”一词在过去曾被广泛使用,但现在任何提及,即使是缩写,也会被视为冒犯。本文讨论了与“智力迟钝”相关的污名化问题,这种污名化会导致歧视;在这些命名中使用“智力迟钝”是不准确的;脆性 X 综合征的范围超出了神经多样性。因此需要使用更具包容性的术语,不再使用任何与“智力迟钝”相关的词汇。本文还列出了修改冒犯性基因名称的先例。建议向 HGNC(HUGO [人类基因组组织]基因命名委员会)提出新的术语建议。欢迎该领域的其他研究人员提出想法。
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