Mozaffari Abolfazl, Parvinzadeh Gashti Mazeyar
Department of Textile Engineering, Yazd Branch, Islamic Azad University, Yazd 8915813135, Iran.
Research and Development Laboratory, PRE Labs Inc., 3302 Appaloosa Road, Unit 3, Kelowna, BC V1X 7Y5, Canada.
Biomedicines. 2022 Mar 7;10(3):617. doi: 10.3390/biomedicines10030617.
Nowadays, gelatin, a molecular derivative of collagen, has gained increasing interest in tissue engineering applications due to excellent biocompatibility, biodegradability, availability, process simplicity, and low costs. In this study, we fabricated tannic acid-crosslinked gelatin nanofibers by electrospinning method. In order to increase the bio-functionality of scaffolds, they were exposed to the atmospheric air plasma. Several analytical tools were used for evaluation of nanofibers including scanning electron microscopy (SEM), atomic force microscopy (AFM), attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, X-ray diffraction (XRD), and water contact angle equipment (CA) together with biocompatibility study using fibroblast cells. Results demonstrated that atmospheric air plasma is not only able to improve the hydrophilicity of nanofibers but it also improves the bio-functionality against human skin fibroblast cells. Hence, we recommend atmospheric air plasma pre-treatment approach for the surface functionalization of gelatin nanofibers for skin tissue engineering applications.
如今，明胶作为胶原蛋白的一种分子衍生物，因其出色的生物相容性、生物降解性、可得性、工艺简单性和低成本，在组织工程应用中越来越受到关注。在本研究中，我们通过静电纺丝法制备了单宁酸交联的明胶纳米纤维。为了提高支架的生物功能性，将它们暴露于大气空气等离子体中。使用了几种分析工具来评估纳米纤维，包括扫描电子显微镜（SEM）、原子力显微镜（AFM）、衰减全反射傅里叶变换红外（ATR-FTIR）光谱、X射线衍射（XRD）和水接触角测量仪（CA），以及使用成纤维细胞进行生物相容性研究。结果表明，大气空气等离子体不仅能够提高纳米纤维的亲水性，还能改善其对人皮肤成纤维细胞的生物功能性。因此，我们推荐将大气空气等离子体预处理方法用于明胶纳米纤维的表面功能化，以用于皮肤组织工程应用。
Zotero 插件
