Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, China.
Genes (Basel). 2022 Feb 27;13(3):439. doi: 10.3390/genes13030439.
In order to investigate the association between serum periostin levels and the variation of its encoding gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women, an association study was performed.
385 postmenopausal women were recruited. For participants without a history of vertebral fracture, lateral X-rays of the spine covering the fourth thoracic spine to the fifth lumbar spine were performed to detect any asymptomatic vertebral fractures. Ten tag-single nucleotide polymorphisms (SNP) of were genotyped. Serum periostin levels, biochemical parameters, and BMD were measured individually.
rs9603226 was significantly associated with vertebral fractures. Compared to allele G, the minor allele A carriers of rs9603226 had a 1.722-fold higher prevalence of vertebral fracture ( = 0.037). rs3923854 was significantly associated with the serum periostin level. G/G genotype of rs3923854 had a higher serum periostin level than C/C and C/G (67.26 ± 19.90 ng/mL vs. 54.57 ± 21.44 ng/mL and 54.34 ± 18.23 ng/mL). Furthermore, there was a negative correlation between the serum level of periostin and BMD at trochanter and total hip.
Our study suggested that genetic variation of could be a predicting factor for the risk of vertebral fractures. The serum level of periostin could be a potential biochemical parameter for osteoporosis in Chinese postmenopausal women.
为了探讨血清骨膜蛋白水平及其编码基因变异与中国绝经后妇女椎体骨折和骨密度（BMD）患病率之间的关系，进行了一项相关性研究。
共纳入 385 例绝经后妇女。对于无椎体骨折史的患者，进行了第四胸椎至第五腰椎侧位 X 光片检查，以检测有无无症状性椎体骨折。对 进行了 10 个标签单核苷酸多态性（SNP）的基因分型。单独测量血清骨膜蛋白水平、生化参数和 BMD。
rs9603226 与椎体骨折显著相关。与等位基因 G 相比，rs9603226 的次要等位基因 A 携带者椎体骨折的患病率增加了 1.722 倍（ = 0.037）。rs3923854 与血清骨膜蛋白水平显著相关。rs3923854 的 G/G 基因型的血清骨膜蛋白水平高于 C/C 和 C/G 基因型（67.26 ± 19.90 ng/mL 比 54.57 ± 21.44 ng/mL 和 54.34 ± 18.23 ng/mL）。此外，血清骨膜蛋白水平与转子间和全髋关节的 BMD 呈负相关。
本研究表明，periostin 基因的遗传变异可能是椎体骨折风险的预测因素。血清骨膜蛋白水平可能是中国绝经后妇女骨质疏松症的潜在生化参数。
