ADAMTS7 基因 rs3825807 多态性与 2 型糖尿病合并心肌梗死患者的相关性研究
The rs3825807 Polymorphism of ADAMTS7 as a Potential Genetic Marker for Myocardial Infarction in Slovenian Subjects with Type 2 Diabetes Mellitus.
机构信息
Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
Laboratory for Histology and Genetics of Atherosclerosis and Microvascular Diseases, Institute of Histology and Embryology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia.
出版信息
Genes (Basel). 2023 Feb 16;14(2):508. doi: 10.3390/genes14020508.
BACKGROUND
A disintegrin and metalloprotease with thrombospondin motif 7 (ADAMTS-7) was reported to play a role in the migration of vascular smooth muscle cells and neointimal formation. The object of the study was to investigate the association between the rs3825807 polymorphism of ADAMTS7 and myocardial infarction among patients with type 2 diabetes mellitus in a Slovenian cohort.
METHODS
1590 Slovenian patients with type 2 diabetes mellitus were enrolled in this retrospective cross-sectional case-control study. In total, 463 had a history of recent myocardial infarction, and 1127 of the subjects in the control group had no clinical signs of coronary artery disease. Genetic analysis of an rs3825807 polymorphism of ADAMTS7 was performed with logistic regression.
RESULTS
Patients with the AA genotype had a higher prevalence of myocardial infarction than those in the control group in recessive [odds ratio (OR) 1.647; confidence interval (CI) 1.120-2.407; = 0.011] and co-dominant (OR 2.153; CI 1.215-3.968; = 0.011) genetic models.
CONCLUSION
We found a statistically significant association between rs3825807 and myocardial infarction in a cohort of Slovenian patients with type 2 diabetes mellitus. We report that the AA genotype might be a genetic risk factor for myocardial infarction.
背景
解整合素金属蛋白酶 7（ADAMTS-7）被报道在血管平滑肌细胞迁移和新生内膜形成中发挥作用。本研究旨在探讨 ADAMTS7 的 rs3825807 多态性与 2 型糖尿病患者心肌梗死之间的关系。
方法
本回顾性横断面病例对照研究纳入了 1590 名 2 型糖尿病的斯洛文尼亚患者。其中，463 例患者有近期心肌梗死病史，1127 例对照组患者无冠状动脉疾病的临床症状。采用 logistic 回归分析 ADAMTS7 的 rs3825807 多态性。
结果
与对照组相比，隐性遗传模型中 AA 基因型患者的心肌梗死发生率更高[比值比（OR）1.647；95%置信区间（CI）1.120-2.407；P=0.011]，共显性遗传模型中 AA 基因型患者的心肌梗死发生率也更高[OR 2.153；95%CI 1.215-3.968；P=0.011]。
结论
我们在 2 型糖尿病的斯洛文尼亚患者队列中发现 rs3825807 与心肌梗死之间存在统计学显著关联。我们报告 AA 基因型可能是心肌梗死的遗传危险因素。
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