Department of Biology, School of Science and Technology, University of Évora, 7006-554 Évora, Portugal.
Comprehensive Health Research Centre (CHRC), University of Évora, 7002-554 Évora, Portugal.
Int J Mol Sci. 2022 Mar 11;23(6):3046. doi: 10.3390/ijms23063046.
The permanent exposure to environmental contaminants promoting weight gain (i.e., obesogens) has raised serious health concerns. Evidence suggests that obesogens are one of the leading causes of the marked decline in male fertility and are key players in shaping future health outcomes, not only for those who are directly exposed to them, but also for upcoming generations. It has been hypothesized that obesogens affect male fertility. By using an interdisciplinary strategy, combining in silico, in vitro, in vivo and epidemiological findings, this review aims to contribute to the biological understanding of the molecular transformations induced by obesogens that are the basis of male infertility. Such understanding is shaped by the use of Adverse Outcomes Pathways, a new approach that may shift the paradigm of reproductive toxicology, contributing to the improvement of the diagnosis and management of the adverse effects of obesogens in male fertility.
长期暴露于促进体重增加的环境污染物（即肥胖物）引起了严重的健康问题。有证据表明，肥胖物是导致男性生育力显著下降的主要原因之一，也是影响未来健康结果的关键因素，不仅对那些直接接触它们的人，而且对即将到来的后代也是如此。有人假设肥胖物会影响男性生育力。本综述采用了一种跨学科的策略，结合了计算机模拟、体外、体内和流行病学研究结果，旨在促进对肥胖物引起的男性不育的分子变化的生物学理解。这种理解是通过使用不良结局途径（一种新的方法）来实现的，这种方法可能会改变生殖毒理学的范式，有助于改善肥胖物对男性生育力的不良影响的诊断和管理。
