Vienna University of Technology, Faculty of Technical Chemistry, Institute of Applied Synthetic Chemistry, Institute of Chemical Technologies and Analytics, Getreidemarkt 9/163-164, 1060 Vienna, Austria.
Vienna University of Technology, Faculty of Technical Chemistry, Institute of Applied Synthetic Chemistry, Institute of Chemical Technologies and Analytics, Getreidemarkt 9/163-164, 1060 Vienna, Austria.
Curr Opin Biotechnol. 2019 Feb;55:81-86. doi: 10.1016/j.copbio.2018.08.009. Epub 2018 Sep 4.
Organ-on-a-chip technology offers the potential to recapitulate human physiology by keeping human cells in a precisely controlled and artificial tissue-like microenvironment. The current and potential advantages of organs-on-chips over conventional cell cultures systems and animal models have captured the attention of scientists, clinicians and policymakers as well as advocacy groups in the past few years. Recent advances in tissue engineering and stem cell research are also aiding the development of clinically relevant chip-based organ and diseases models with organ level physiology for drug screening, biomedical research and personalized medicine. Here, the latest advances in organ-on-a-chip technology are reviewed and future clinical applications discussed.
器官芯片技术通过将人类细胞置于精确控制的人工组织样微环境中，提供了重现人体生理学的潜力。在过去的几年中，器官芯片相对于传统细胞培养系统和动物模型的当前和潜在优势引起了科学家、临床医生和政策制定者以及倡导团体的关注。组织工程和干细胞研究的最新进展也有助于开发具有器官水平生理学的基于芯片的临床相关器官和疾病模型，用于药物筛选、生物医学研究和个性化医疗。本文综述了器官芯片技术的最新进展，并讨论了未来的临床应用。
