Department of Pathology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Department of Immunology, School of Medicine, Catholic University of Daegu, Gyeongsan 42472, Korea.
Int J Mol Sci. 2022 Mar 15;23(6):3152. doi: 10.3390/ijms23063152.
Acne vulgaris is the most common disease of the pilosebaceous unit. The pathogenesis of this disease is complex, involving increased sebum production and perifollicular inflammation. Understanding the factors that regulate sebum production is important in identifying novel therapeutic targets for the treatment of acne. Bee Venom (BV) and melittin have multiple effects including antibacterial, antiviral, and anti-inflammatory activities in various cell types. However, the anti-lipogenic mechanisms of BV and melittin have not been elucidated. We investigated the effects of BV and melittin in models of Insulin-like growth factor-1 (IGF-1) or ()-induced lipogenic skin disease. or IGF-1 increased the expression of sterol regulatory element-binding protein-1 (SREBP-1) and proliferator-activated receptor gamma (PPAR-γ), transcription factors that regulate numerous genes involved in lipid biosynthesis through the protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/SREBP signaling pathway. In this study using a or IGF-1 stimulated lipogenic disease model, BV and melittin inhibited the increased expression of lipogenic and pro-inflammatory factor through the blockade of the Akt/mTOR/SREBP signaling pathway. This study suggests for the first time that BV and melittin could be developed as potential natural anti-acne agents with anti-lipogenesis, anti-inflammatory, and anti- activity.
寻常痤疮是最常见的皮肤附属器疾病。该病的发病机制复杂，涉及皮脂分泌增加和毛囊周围炎症。了解调节皮脂分泌的因素对于确定治疗痤疮的新治疗靶点非常重要。蜂毒（BV）和蜂毒素具有多种作用，包括在各种细胞类型中具有抗菌、抗病毒和抗炎活性。然而，BV 和蜂毒素的抗脂肪生成机制尚未阐明。我们研究了 BV 和蜂毒素在胰岛素样生长因子-1（IGF-1）或（）诱导的脂肪生成皮肤疾病模型中的作用。IGF-1 或 IGF-1 通过蛋白激酶 B（Akt）/哺乳动物雷帕霉素靶蛋白（mTOR）/固醇调节元件结合蛋白-1（SREBP-1）和增殖物激活受体γ（PPAR-γ）的表达增加，调节许多参与脂质生物合成的基因的转录因子。在这项研究中，使用 IGF-1 刺激的脂肪生成疾病模型，BV 和蜂毒素通过阻断 Akt/mTOR/SREBP 信号通路抑制脂肪生成和促炎因子的表达增加。这项研究首次表明，BV 和蜂毒素可以开发为具有抗脂肪生成、抗炎和抗活性的潜在天然抗痤疮药物。
