Division of Pharmacology, Otto Loewi Research Center, Medical University of Graz, 8010 Graz, Austria.
Int J Mol Sci. 2022 Mar 16;23(6):3218. doi: 10.3390/ijms23063218.
Neutrophils are immune cells with reported phenotypic and functional plasticity. Tumor-associated neutrophils display many roles during cancer progression. Several tumor microenvironment (TME)-derived factors orchestrate neutrophil release from the bone marrow, recruitment and functional polarization, while simultaneously neutrophils are active stimulators of the TME by secreting factors that affect immune interactions and subsequently tumor progression. Successful immunotherapies for many cancer types and stages depend on the targeting of tumor-infiltrating lymphocytes. Neutrophils impact the success of immunotherapies, such as immune checkpoint blockade therapies, by displaying lymphocyte suppressive properties. The identification and characterization of distinct neutrophil subpopulations or polarization states with pro- and antitumor phenotypes and the identification of the major TME-derived factors of neutrophil polarization would allow us to harness the full potential of neutrophils as complementary targets in anticancer precision therapies.
中性粒细胞是具有报道的表型和功能可塑性的免疫细胞。肿瘤相关中性粒细胞在癌症进展过程中具有多种作用。几种肿瘤微环境 (TME) 衍生因子协调骨髓中中性粒细胞的释放、募集和功能极化，而中性粒细胞同时通过分泌影响免疫相互作用并随后影响肿瘤进展的因子，积极地刺激 TME。许多癌症类型和阶段的成功免疫疗法取决于针对肿瘤浸润淋巴细胞的靶向治疗。中性粒细胞通过显示淋巴细胞抑制特性来影响免疫检查点阻断疗法等免疫疗法的成功。鉴定和表征具有促肿瘤和抗肿瘤表型的不同中性粒细胞亚群或极化状态，以及鉴定中性粒细胞极化的主要 TME 衍生因子，将使我们能够充分利用中性粒细胞作为抗癌精准治疗中互补的靶标。
