Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, State Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan University, Shanghai 200433, China.
Cancer Biol Med. 2024 Sep 19;21(10):849-63. doi: 10.20892/j.issn.2095-3941.2024.0192.
Neutrophils, which originate from the bone marrow and are characterized by a segmented nucleus and a brief lifespan, have a crucial role in the body's defense against infections and acute inflammation. Recent research has uncovered the complex roles of neutrophils as regulators in tumorigenesis, during which neutrophils exhibit a dualistic nature that promotes or inhibits tumor progression. This adaptability is pivotal within the tumor microenvironment (TME). In this review, we provide a comprehensive characterization of neutrophil plasticity and heterogeneity, aiming to illuminate current research findings and discuss potential therapeutic avenues. By delineating the intricate interplay of neutrophils in the TME, this review further underscores the urgent need to understand the dual functions of neutrophils with particular emphasis on the anti-tumor effects to facilitate the development of effective therapeutic strategies against cancer.
中性粒细胞起源于骨髓，具有核分叶和短暂寿命的特点，在机体抗感染和急性炎症反应中发挥着关键作用。最近的研究揭示了中性粒细胞作为肿瘤发生过程中调节者的复杂作用，在此过程中，中性粒细胞表现出促进或抑制肿瘤进展的双重特性。这种适应性在肿瘤微环境（TME）中至关重要。在本综述中，我们全面描述了中性粒细胞的可塑性和异质性，旨在阐明当前的研究结果，并讨论潜在的治疗途径。通过阐述中性粒细胞在 TME 中的复杂相互作用，本综述进一步强调了迫切需要理解中性粒细胞的双重功能，特别要强调其抗肿瘤作用，以促进针对癌症的有效治疗策略的发展。
