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低密度中性粒细胞：理解口腔鳞状细胞癌肿瘤微环境的关键组成部分。

Low-density neutrophils: A critical component in understanding the tumor microenvironment of oral squamous cell carcinoma.

作者信息

Dineshkumar Thayalan, Anandan Nirmala, Krishnan Rajkumar, Nandhakumar Indumathi

机构信息

Department of Oral Pathology and Microbiology, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

Department of Biochemistry, SRM Dental College, Ramapuram, Chennai, Tamil Nadu, India.

出版信息

J Oral Maxillofac Pathol. 2025 Apr-Jun;29(2):172-178. doi: 10.4103/jomfp.jomfp_351_24. Epub 2025 Jun 30.

DOI:10.4103/jomfp.jomfp_351_24
PMID:40703833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12283039/
Abstract

BACKGROUND

Tumour microenvironment is one of the evading research studies in the progression of cancers. Circulating neutrophil's contribution to tumor growth and metastatic progression has been a matter of research interest. The phenotypic subset of low-density neutrophils (LDNs) has been seen as closely associated with disease severity in various cancers.

AIM AND OBJECTIVES

This study aims to investigate the LDN and normal-density neutrophil (NDN) populations in oral cancer.

MATERIALS AND METHODS

This is prospective research in which the CD16+ population was magnetically sorted and leukocytes were separated in a density gradient. Using a flow cytometer, the percentages of the neutrophil subpopulation were ascertained. It was established that there are two distinct populations of human neutrophils: LDNs and NDNs.

RESULTS

Patients with oral squamous cell carcinoma (OSCC) showed a higher percentage of LDN/NDN ratio and a correspondingly lower percentage of LDN/NDN ratio when compared to the control group. In addition, patients with OSCC had higher neutrophil-to-lymphocyte ratios (NLRs).

CONCLUSION

The current study showed a significant correlation between the LDN/NDN ratio in OSCC, which could be used as a benchmark for novel treatments. Additionally, the acquired LDNs/NDNs and NLR levels in cancer patients demonstrate their importance in OSCC patient prognosis and diagnosis.

摘要

背景

肿瘤微环境是癌症进展中一项仍在深入研究的领域。循环中性粒细胞对肿瘤生长和转移进展的作用一直是研究热点。低密度中性粒细胞（LDNs）的表型亚群被认为与多种癌症的疾病严重程度密切相关。

目的

本研究旨在调查口腔癌中的LDN和正常密度中性粒细胞（NDN）群体。

材料与方法

这是一项前瞻性研究，其中通过磁性分选CD16 +群体，并在密度梯度中分离白细胞。使用流式细胞仪确定中性粒细胞亚群的百分比。已确定人类中性粒细胞有两个不同的群体：LDNs和NDNs。

结果

与对照组相比，口腔鳞状细胞癌（OSCC）患者的LDN/NDN比值百分比更高，相应地LDN/NDN比值百分比更低。此外，OSCC患者的中性粒细胞与淋巴细胞比值（NLRs）更高。

结论

当前研究表明OSCC中LDN/NDN比值之间存在显著相关性，这可作为新治疗方法的基准。此外，癌症患者获得的LDNs/NDNs和NLR水平证明了它们在OSCC患者预后和诊断中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6437/12283039/2bef7267ef0e/JOMFP-29-172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6437/12283039/2bef7267ef0e/JOMFP-29-172-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6437/12283039/2bef7267ef0e/JOMFP-29-172-g001.jpg

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本文引用的文献

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Quantitative Proteomic Analysis of Non-Tobacco Associated Oral Squamous Cell Carcinoma Reveals Deregulation of Cytoskeletal and Apoptotic Proteins.非烟草相关口腔鳞状细胞癌的定量蛋白质组学分析揭示细胞骨架和凋亡蛋白的失调。
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Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies.
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Int J Mol Sci. 2022 Dec 13;23(24):15827. doi: 10.3390/ijms232415827.
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Tumor-Mediated Neutrophil Polarization and Therapeutic Implications.肿瘤介导的中性粒细胞极化及其治疗意义。
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