Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO 63110, USA.
Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.
Int J Environ Res Public Health. 2022 Mar 11;19(6):3297. doi: 10.3390/ijerph19063297.
The aims of this study were to (1) determine the feasibility of a home-based resistance exercise training (RET) program in patients with cystic fibrosis and impaired glucose tolerance using virtual personal training and (2) observe the effects completion of the RET program had on glucose metabolism, pulmonary function, body composition, and physical fitness. The feasibility of the program was defined as 80% compliance. Ten participants (15.80 ± 2.20 yr, 25.1 ± 7.4 kg/m) began a home-based resistance training program consisting of 36 sessions supervised via online videoconferencing. Compliance scores of 78.9% (all participants) and 81.8% (without one outlier) were observed. A significant increase was observed in 2-h C-peptide levels (2.1 ng/mL; = 0.04), with a moderate decrease in fasting glucose (-5.2 mg/dL; = 0.11) and a moderate increase in 2-h insulin (35.0 U/mL; = 0.10). A small decrease in the fat percentage (-1.3%; = 0.03) was observed in addition to increases in fat-free mass (1.5 kg; = 0.01) and the fat-free mass index (0.4; = 0.01). Small, yet statistically significant increases were observed in V̇O (0.1 L/min = 0.01), V̇CO (0.1 L/min; = 0.01), and ventilation (5.3 L/min; = 0.04). Telehealth-based RET is feasible in adolescents with CF and impaired glucose tolerance and elicits small yet favorable changes in insulin secretion, body composition, and exercise capacity.
（1）利用虚拟私人教练，确定在家进行的抵抗运动训练（RET）计划在患有囊性纤维化和糖耐量受损的患者中的可行性；（2）观察完成 RET 计划对葡萄糖代谢、肺功能、身体成分和身体适应性的影响。该计划的可行性定义为 80%的依从性。10 名参与者（15.80±2.20 岁，25.1±7.4kg/m）开始了一项基于家庭的抵抗训练计划，该计划包括 36 次在线视频会议监督的课程。观察到的依从性评分为 78.9%（所有参与者）和 81.8%（无一个异常值）。观察到 2 小时 C 肽水平（2.1ng/mL； = 0.04）显著增加，空腹血糖（-5.2mg/dL； = 0.11）适度降低，2 小时胰岛素（35.0U/mL； = 0.10）适度增加。此外，还观察到脂肪百分比（-1.3%； = 0.03）略有下降，脂肪量（1.5kg； = 0.01）和脂肪量指数（0.4； = 0.01）增加。观察到 V̇O（0.1L/min=0.01）、V̇CO（0.1L/min； = 0.01）和通气（5.3L/min； = 0.04）的小而有统计学意义的增加。基于远程医疗的 RET 在患有 CF 和糖耐量受损的青少年中是可行的，并且在胰岛素分泌、身体成分和运动能力方面产生了小而有利的变化。
