联合运动训练改善成年囊性纤维化患者的血糖控制。
Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis.
作者信息
Beaudoin Nadia, Bouvet Guillaume F, Coriati Adèle, Rabasa-Lhoret Rémi, Berthiaume Yves
机构信息
1Institut de Recherches Cliniques de Montreal (IRCM), Montreal, Quebec, CANADA; 2Cystic Fibrosis Clinic, Centre Hospitalier de l'Universite de Montreal (CHUM), Montreal, Quebec, CANADA; 3Department of Nutrition, Montreal University, Montreal, Quebec, CANADA; and 4Department of Medecine, Montreal University, Montreal, Quebec, CANADA.
出版信息
Med Sci Sports Exerc. 2017 Feb;49(2):231-237. doi: 10.1249/MSS.0000000000001104.
PURPOSE
Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 patients with diabetes demonstrated an improvement of glycemic control. The aim of the study was to determine whether a combined exercise program is beneficial to improve plasma glucose at 2 h of the oral glucose tolerance test in CF.
METHOD
Eighteen adults with CF with glucose abnormality were recruited (Clinicaltrial.gov: NTC02127957), and 17 were randomly assigned to a control or exercise group for 12 wk. V˙O2max, oral glucose tolerance test, muscular endurance and strength, and quality of life were measured pre- and postintervention.
RESULTS
Fourteen participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (-2.34 ± 1.26 mmol·L, P < 0.007, confidence interval = 99.22%) and presented a reduction of 17.2% (P < 0.05) in total glucose excursion. No significant change for other parameters was observed.
CONCLUSION
A combined exercise program improves glycemic control in CF.
目的
葡萄糖异常和糖尿病是囊性纤维化（CF）最常见的合并症。针对2型糖尿病患者的联合（有氧和抗阻）运动计划已证明可改善血糖控制。本研究的目的是确定联合运动计划是否有助于改善CF患者口服葡萄糖耐量试验2小时时的血糖水平。
方法
招募了18名患有葡萄糖异常的成年CF患者（Clinicaltrial.gov：NTC02127957），其中17名被随机分配至对照组或运动组，为期12周。在干预前后测量了最大摄氧量、口服葡萄糖耐量试验、肌肉耐力和力量以及生活质量。
结果
14名参与者完成了方案。运动组患者的2小时血糖值显著改善（-2.34±1.26 mmol·L，P<0.007，置信区间=99.22%），总血糖波动降低了17.2%（P<0.05）。未观察到其他参数有显著变化。
结论
联合运动计划可改善CF患者的血糖控制。
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