Pepelassi Eudoxie, Deligianni Maria
Department of Periodontology, School of Dentistry, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
Bioinformatics and Computational Biology, School of Science, Department of Biology, National and Kapodistrian University of Athens, 157 01 Athens, Greece.
Materials (Basel). 2022 Mar 11;15(6):2088. doi: 10.3390/ma15062088.
The aim of this systematic review of randomized controlled trials was to evaluate the adjunctive use of leucocyte- and platelet-rich fibrin (L-PRF) in periodontal endosseous and furcation defects, as compared without L-PRF. The endosseous defect group was subclassified into: L-PRF/open flap debridement (L-PRF/OFD) versus OFD, L-PRF/osseous graft (L-PRF/OG) versus OG, L-PRF/Emdogain (L-PRF/EMD) versus EMD, and L-PRF/guided tissue regeneration (L-PRF/GTR) versus GTR. The furcation defect group was subclassified into L-PRF/OFD versus OFD, and L-PRF/OG versus OG. Mean difference, 95% confidence intervals and forest plots were calculated for probing pocket depth (PPD), clinical attachment level (CAL) and radiographic defect depth (DD). Nineteen studies concerning systemically healthy non-smokers were included. The results of this systematic review and meta-analysis showed in two- and/or three-wall endosseous defects that the adjunctive use of L-PRF to OFD or OG was significantly beneficial for PPD reduction, CAL gain and DD reduction, as compared without L-PRF. Furthermore, the data showed that for two- and/or three-wall endosseous defects, the adjunctive use of L-PRF to GTR was significantly beneficial for CAL and DD improvement, whereas adding L-PRF to EMD had no significant effect, and that for class II furcation defects, the addition of L-PRF to OFD was significantly beneficial for PPD, CAL and DD improvement, whereas the addition of L-PRF to OG was significantly clinically beneficial. In conclusion, this systematic review and meta-analysis found that there was significant clinical and radiographic additive effectiveness of L-PRF to OFD and to OG in two- and/or three-wall periodontal endosseous defects of systemically healthy non-smokers, as compared without L-PRF.
本随机对照试验的系统评价旨在评估富白细胞和血小板纤维蛋白（L-PRF）在牙周骨内和根分叉缺损中的辅助应用，并与未使用L-PRF的情况进行比较。骨内缺损组进一步分为：L-PRF/开放瓣清创术（L-PRF/OFD）与OFD、L-PRF/骨移植（L-PRF/OG）与OG、L-PRF/釉基质蛋白（L-PRF/EMD）与EMD、L-PRF/引导组织再生（L-PRF/GTR）与GTR。根分叉缺损组进一步分为L-PRF/OFD与OFD、L-PRF/OG与OG。计算了探诊深度（PPD）、临床附着水平（CAL）和影像学缺损深度（DD）的平均差异、95%置信区间和森林图。纳入了19项关于全身健康非吸烟者的研究。本系统评价和荟萃分析的结果表明，在两壁和/或三壁骨内缺损中，与未使用L-PRF相比，L-PRF辅助OFD或OG在减少PPD、增加CAL和减少DD方面具有显著益处。此外，数据表明，对于两壁和/或三壁骨内缺损，L-PRF辅助GTR在改善CAL和DD方面具有显著益处，而在EMD中添加L-PRF没有显著效果，对于II类根分叉缺损，L-PRF辅助OFD在改善PPD、CAL和DD方面具有显著益处，而L-PRF辅助OG具有显著的临床益处。总之，本系统评价和荟萃分析发现，与未使用L-PRF相比，在全身健康非吸烟者的两壁和/或三壁牙周骨内缺损中，L-PRF辅助OFD和OG具有显著的临床和影像学附加疗效。
