Morishima Y
Gan To Kagaku Ryoho. 1986 Oct;13(10):2922-9.
Bone marrow transplantation (BMT) has been done as one mode of cancer therapy which has the possibility of curing some cancer patients. In Nagoya, more than half of leukemia patients who received allogeneic BMT in a remission state became long-term survivors, and autologous BMT for acute lymphoblastic leukemia has been successfully done using monoclonal antibodies for purging leukemia cells from bone marrow. According to our experiences with leukemia BMT, the following essential conditions for performing successful BMT in cancer patients were discussed, 1) preconditioning therapy for eradication of cancer cells, 2) supportive care for prevention of side effects of BMT including virus infections such as cytomegalovirus, and 3) compatibility of HLA antigens.
骨髓移植（BMT）已作为一种癌症治疗方式开展，它有可能治愈一些癌症患者。在名古屋，超过半数处于缓解期接受异基因BMT的白血病患者成为长期存活者，并且使用单克隆抗体从骨髓中清除白血病细胞，已成功完成了急性淋巴细胞白血病的自体BMT。根据我们白血病BMT的经验，讨论了在癌症患者中成功进行BMT的以下基本条件：1）用于根除癌细胞的预处理疗法；2）用于预防BMT副作用（包括巨细胞病毒等病毒感染）的支持性护理；3）HLA抗原的相容性。
