Gent H J, Sprenger E, Dowlatshahi K
Ann Surg. 1986 Nov;204(5):580-4. doi: 10.1097/00000658-198611000-00012.
A stereotaxic technique for localization of occult breast lesions and fine needle aspiration for cytological diagnosis was used on examination of 543 patients. Successful localization with the needle tip within 1 mm of the suspected lesion was possible in 490 patients (90.2%). Based on a high mammographic index of suspicion for malignancy, 187 of 490 patients were selected to undergo open biopsy, following aspiration cytology and localization with methylene blue injection. The statistical results (cytologic vs. histologic examination) revealed a sensitivity of 97.5% and a specificity of 95.2% for cytologic diagnosis of occult breast lesions. The technique is easy to learn and takes 20-30 minutes to perform. Compliance was 100% and complications were nil. This new technique expedites localization and maximizes the specificity of mammography for occult breast lesions.
对543例患者进行检查时，采用立体定向技术定位隐匿性乳腺病变，并进行细针穿刺抽吸以进行细胞学诊断。490例患者（90.2%）的针尖成功定位在距疑似病变1毫米范围内。基于对恶性肿瘤的高乳腺钼靶怀疑指数，490例患者中有187例在进行抽吸细胞学检查并用亚甲蓝注射定位后接受了开放活检。统计结果（细胞学检查与组织学检查）显示，隐匿性乳腺病变细胞学诊断的敏感性为97.5%，特异性为95.2%。该技术易于学习，操作需要20至30分钟。依从性为100%，无并发症。这项新技术加快了定位速度，并最大限度地提高了乳腺钼靶对隐匿性乳腺病变的特异性。
