Holland R, Hendriks J H, Mravunac M
Cancer. 1983 Nov 15;52(10):1810-9. doi: 10.1002/1097-0142(19831115)52:10<1810::aid-cncr2820521009>3.0.co;2-f.
Fifteen mammographically occult breast cancers, 3 of which were preinvasive and 12 invasive, and 52 breast cancers, which presented only microcalcifications mammographically without an associated tumor shadow (33 preinvasive and 19 invasive), were reviewed pathologically and radiologically. This study suggests that most of the preinvasive cancers, without mammographically significant calcifications, are, and some of the invasive cancers situated in dense breasts may be, mammographically occult. The mean diameter of the five mammographically occult invasive ductal carcinomas and the five invasive lobular carcinomas was 20 mm and 50 mm, respectively. Histologic characteristics, which may explain why invasive lobular carcinomas could be occult mammographically, even in an advanced stage, include a diffuse invasive pattern and, frequently, a poor desmoplastic reaction in contrast to the invasive ductal carcinomas. The implications of mammographically occult cancers on management of symptomatic and asymptomatic patients are discussed.
对15例乳腺钼靶隐匿性乳腺癌（其中3例为原位癌，12例为浸润性癌）以及52例仅在乳腺钼靶上表现为微小钙化而无相关肿瘤阴影的乳腺癌（33例原位癌和19例浸润性癌）进行了病理和放射学检查。本研究表明，大多数无乳腺钼靶显著钙化的原位癌以及一些位于致密乳腺中的浸润性癌在乳腺钼靶上可能是隐匿的。5例乳腺钼靶隐匿性浸润性导管癌和5例浸润性小叶癌的平均直径分别为20毫米和50毫米。组织学特征，这可能解释了为什么浸润性小叶癌即使在晚期在乳腺钼靶上也可能是隐匿的，包括弥漫性浸润模式，并且与浸润性导管癌相比，通常促纤维增生反应较差。讨论了乳腺钼靶隐匿性癌对有症状和无症状患者管理的影响。
