Dark J H, Patterson G A, Al-Jilaihawi A N, Hsu H, Egan T, Cooper J D
Ann Thorac Surg. 1986 Oct;42(4):394-8. doi: 10.1016/s0003-4975(10)60544-9.
A technique of en bloc double-lung transplantation through a median sternotomy has been developed. Hypothermic circulatory arrest was used after surface cooling in 7 puppies (mean weight, 3.1 kg; range, 1.5 to 4.1 kg). A double lung block, consisting of the two lungs, distal trachea, the main pulmonary artery, and a large cuff of left atrium, was removed from weight-matched donors. After the arrest of the circulation by inflow occlusion, bilateral pneumonectomies were performed in the recipient. The donor double-lung block was then implanted with anastomoses at the distal trachea, the posterior left atrium, and the main pulmonary artery. All animals were successfully rewarmed and had excellent hemodynamic function and gas exchange for periods of up to 24 hours. If primate experiments with long-term survival confirm these initial results, this procedure may have a role in the treatment of patients with end-stage respiratory disease but acceptable cardiac function.
已经开发出一种通过正中胸骨切开术进行整块双肺移植的技术。7只幼犬（平均体重3.1千克；范围1.5至4.1千克）在体表降温后采用低温循环停止。从体重匹配的供体中取出由双肺、远端气管、主肺动脉和一大块左心房袖口组成的双肺块。在通过流入闭塞使循环停止后，对受体进行双侧肺切除术。然后将供体双肺块植入，在远端气管、左心房后部和主肺动脉处进行吻合。所有动物均成功复温，在长达24小时的时间内具有良好的血流动力学功能和气体交换。如果灵长类动物的长期存活实验证实了这些初步结果，那么该手术可能在治疗终末期呼吸系统疾病但心脏功能尚可的患者中发挥作用。
