腹部手术中粘连预防试验的未来：一项全球专家共识

De Wilde Rudy Leon, Devassy Rajesh, Broek Richard P G Ten, Miller Charles E, Adlan Aizura, Aquino Prudence, Becker Sven, Darmawan Ferry, Gergolet Marco, Habana Maria Antonia E, Khoo Chong Kiat, Koninckx Philippe R, Korell Matthias, Krentel Harald, Musigavong Olarik, Pistofidis George, Puntambekar Shailesh, Rachman Ichnandy A, Sendag Fatih, Wallwiener Markus, Torres-de la Roche Luz Angela

University Hospital for Gynecology, Carl von Ossietzky University, 26121 Oldenburg, Germany.

Centre of Excellence in Gynecological Minimal Access Surgery and Oncology, Dubai London Clinic & Specialty Hospital, Dubai 3371500, United Arab Emirates.

J Clin Med. 2022 Mar 8;11(6):1476. doi: 10.3390/jcm11061476.

Postoperative adhesions represent a frequent complication of abdominal surgery. Adhesions can result from infection, ischemia, and foreign body reaction, but commonly develop after any surgical procedure. The morbidity caused by adhesions affects quality of life and, therefore, it is paramount to continue to raise awareness and scientific recognition of the burden of adhesions in healthcare and clinical research. This 2021 Global Expert Consensus Group worked together to produce consented statements to guide future clinical research trials and advise regulatory authorities. It is critical to harmonize the expectations of research, to both develop and bring to market improved anti-adhesion therapies, with the ultimate, shared goal of improved patient outcomes.

术后粘连是腹部手术常见的并发症。粘连可由感染、局部缺血和异物反应引起，但通常在任何外科手术后都会发生。粘连引起的发病率会影响生活质量，因此，在医疗保健和临床研究中，继续提高对粘连负担的认识和科学认知至关重要。这个2021年全球专家共识小组共同努力，制定了一致声明，以指导未来的临床研究试验并为监管机构提供建议。协调研究期望至关重要，既要开发并将改进的抗粘连疗法推向市场，最终实现改善患者预后这一共同目标。