Jakubec Petr, Fišerová Kateřina, Genzor Samuel, Kolář Milan
Department of Pulmonary Diseases and Tuberculosis, Faculty of Medicine and Dentistry, Palacký University Olomouc, Hněvotínská 3, 77900 Olomouc, Czech Republic.
Department of Pulmonary Diseases and Tuberculosis, University Hospital Olomouc, I. P. Pavlova 185/6, 77900 Olomouc, Czech Republic.
Life (Basel). 2022 Feb 28;12(3):357. doi: 10.3390/life12030357.
Coronavirus disease 2019 (COVID-19) is a threat to patients not only because of its acute course, but also because of various complications occurring in the following period, that is, more than 28 days after the onset of acute infection. The present study identified a total of 121 patients hospitalized 29 or more days after the first positive result of a PCR test for SARS-CoV-2, of whom 98 patients were included in the study. Patients were divided into two groups by the time interval between the positive COVID-19 test result and hospitalization date. The time intervals were week 5-11 in an ongoing-COVID group (57.1% of patients) and 12 or more weeks in a post-COVID-group (42.9%). The most frequent reason for hospitalization was respiratory tract infection (58.2%). Pneumonia accounted for 77.2% of these cases. Other reasons for hospitalization were interstitial lung disease (22.4%), pulmonary embolism (8.2%), and sarcoidosis (6.1%). The study group was further divided according to the causes of hospitalization into subgroups with infections and other causes. In the group with infectious diseases, there was a shorter time period between PCR positivity and hospitalization and there were significantly more frequent non-respiratory complications. In the entire sample, the in-hospital mortality was 5.1%.
2019冠状病毒病(COVID-19)不仅因其急性病程对患者构成威胁,还因其在急性期之后即急性感染发病28天以后出现的各种并发症而构成威胁。本研究共确定了121例在SARS-CoV-2 PCR检测首次呈阳性结果29天或更长时间后住院的患者,其中98例患者纳入研究。根据COVID-19检测阳性结果与住院日期之间的时间间隔将患者分为两组。正在感染COVID组(占患者的57.1%)的时间间隔为第5至11周,康复后COVID组(占42.9%)的时间间隔为12周或更长时间。住院最常见的原因是呼吸道感染(58.2%)。其中肺炎占这些病例的77.2%。其他住院原因包括间质性肺疾病(22.4%)、肺栓塞(8.2%)和结节病(6.1%)。研究组根据住院原因进一步分为感染组和其他原因组。在传染病组中,PCR检测呈阳性与住院之间的时间较短,非呼吸道并发症明显更常见。在整个样本中,住院死亡率为5.1%。