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质谱成像在泌尿肿瘤学中的应用:发现潜在生物标志物

Application of Mass Spectrometry Imaging in Uro-Oncology: Discovering Potential Biomarkers.

作者信息

Czétány Péter, Gitta Stefánia, Balló András, Sulc Alexandra, Máté Gábor, Szántó Árpád, Márk László

机构信息

National Human Reproduction Laboratory, 7624 Pécs, Hungary.

Urology Clinic, University of Pécs Clinical Centre, 7621 Pécs, Hungary.

出版信息

Life (Basel). 2022 Mar 3;12(3):366. doi: 10.3390/life12030366.

DOI:10.3390/life12030366
PMID:35330118
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8954359/
Abstract

A growing need is emerging worldwide for new molecular markers which could enhance the accuracy of diagnostic and therapeutic methods for detecting urogenital cancers. Mass spectrometry imaging (MSI) is a very promising tool in this regard. In this review, we attempt to provide a subjective summary of the latest publications on potential biomarkers of renal, bladder, prostate, and testicular malignancies detected with MSI through the eyes of a clinical urologist.

摘要

全球对新的分子标志物的需求日益增长,这些标志物可以提高泌尿生殖系统癌症检测的诊断和治疗方法的准确性。在这方面,质谱成像(MSI)是一种非常有前景的工具。在本综述中,我们试图以临床泌尿科医生的视角,对通过MSI检测到的肾、膀胱、前列腺和睾丸恶性肿瘤潜在生物标志物的最新出版物进行主观总结。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/d50b3cbbe558/life-12-00366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/29c79a08954d/life-12-00366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/7dfbeaead419/life-12-00366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/cd582071a623/life-12-00366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/d50b3cbbe558/life-12-00366-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/29c79a08954d/life-12-00366-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/7dfbeaead419/life-12-00366-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/cd582071a623/life-12-00366-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1021/8954359/d50b3cbbe558/life-12-00366-g004.jpg

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Int J Mol Sci. 2020 Dec 18;21(24):9660. doi: 10.3390/ijms21249660.
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Imaging Mass Spectrometry Is an Accurate Tool in Differentiating Clear Cell Renal Cell Carcinoma and Chromophobe Renal Cell Carcinoma: A Proof-of-concept Study.
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J Histochem Cytochem. 2020 Jun;68(6):403-411. doi: 10.1369/0022155420931417. Epub 2020 May 28.
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