Bunning R A, Van Damme J, Richardson H J, Hughes D E, Opdenakker G, Billiau A, Russell R G
Biochem Biophys Res Commun. 1986 Sep 30;139(3):1150-7. doi: 10.1016/s0006-291x(86)80297-2.
The human interferon-beta-inducing 22K factor has been shown to have structural homologies with interleukin-1 beta (IL-1 beta) and some of the activities attributed to IL-1. We have shown that 22K factor, purified to homogeneity and endotoxin free, has connective tissue cell stimulating activities, indicating that these activities are due to a naturally occurring species of IL-1 beta and not contaminating factors. 22K factor stimulated the production of prostaglandin E, caseinase activity and plasminogen activator activity in human articular chondrocytes in culture. This cell system appears highly sensitive to 22K factor activity. 22K factor also stimulated the resorption of bovine nasal cartilage and neonatal mouse calvaria.
人β-干扰素诱导性22K因子已被证明与白细胞介素-1β（IL-1β）具有结构同源性，并具有一些归因于IL-1的活性。我们已经表明，纯化至同质且无内毒素的22K因子具有结缔组织细胞刺激活性，这表明这些活性是由天然存在的IL-1β物种引起的，而非污染因子。22K因子刺激了培养的人关节软骨细胞中前列腺素E的产生、酪蛋白酶活性和纤溶酶原激活剂活性。该细胞系统似乎对22K因子活性高度敏感。22K因子还刺激了牛鼻软骨和新生小鼠颅骨的吸收。
