Rossano C, De Luca L F, Firetto V, Fossi F, Vannini S, Testasecca D, Costantini A, Giugliano F, Fogliardi A, Busca G
Arzneimittelforschung. 1986 Jul;36(7):1100-3.
The analgesic effect and the tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) 200 mg/ml were compared with lysine acetylsalicylate 0.9 g/2.5 ml; the study included 60 subjects in severe to very severe pain following orthopedic surgery. The trial was performed in randomized single-blind fashion in patients who had given informed consent. The substances were injected into the upper out quadrant; maximally 4 intramuscular injections were given within 2 days. The test population was homogeneous with respect to the anamnestic data. The intensity of pain prior to treatment was comparable in both groups. Statistical analysis of the data revealed that suprofen was at the rating times (15 min to 4 h) significantly superior to the control groups. The investigator's and the patients' final appreciation indicated good to very good effect in 93% of the subjects on suprofen, and in 40 and 47%, respectively, of the patients in the control group. Here, too, suprofen was significantly superior to the reference Substance. Systemic and local tolerability of both drugs was very good. Adverse drug experience (heartburn) occurred in only 1 patient in the control group.
将200毫克/毫升的α-甲基-4-(2-噻吩基羰基)苯乙酸（舒洛芬，Suprol）的镇痛效果和耐受性与0.9克/2.5毫升的赖氨酸乙酰水杨酸酯进行了比较；该研究纳入了60名骨科手术后处于重度至极重度疼痛的受试者。试验以随机单盲方式在已签署知情同意书的患者中进行。将药物注射到上外侧象限；在2天内最多进行4次肌肉注射。受试人群在既往病史数据方面具有同质性。两组治疗前的疼痛强度相当。数据的统计分析显示，舒洛芬在各评分时间点（15分钟至4小时）均显著优于对照组。研究者和患者的最终评价表明，93%使用舒洛芬的受试者效果良好至极好，而对照组患者的这一比例分别为40%和47%。同样，舒洛芬也显著优于对照药物。两种药物的全身和局部耐受性都非常好。对照组仅1名患者出现药物不良反应（烧心）。
