Probst G, Michos N
Arzneimittelforschung. 1986 Jul;36(7):1107-9.
Analgesic effect and tolerability of alpha-methyl-4-(2-thienyl-carbonyl)phenylacetic acid (suprofen, Suprol) drops were tested in an open study including 51 informed outpatients with moderate to severe postoperative and posttraumatic pain. Suprofen drops were administered for 7 days, at doses of 33 drops (= 200 mg of suprofen) t.i.d. or q.i.d. The pain intensity was recorded prior to the treatment and after 2, 4 and 7 days; pain relief was assessed on days 2, 4 and 7. Effectiveness and tolerability were by the investigator and by the patients globally evaluated upon completion of the trial. The intensity of pain dropped within the 7-day treatment period from initially severe pain to mild. Pain relief was seen in 92% of the subjects after day 2, in 98% after day 4, and in 100% after day 7 of treatment. Investigator's and patients' final evaluation of the therapeutic effect indicated good analgesic activity in 86% of the population, and very good analgesic effect in 84%. Moderate effect was seen in 12 and 14%, respectively. The tolerability of suprofen drops was by investigator and patients considered good to very good in 82% of the cases, moderate in 16%, and poor in 1 case.
在一项开放性研究中，对51名有知情权的门诊患者进行了α-甲基-4-(2-噻吩基羰基)苯乙酸（舒洛芬，Suprol）滴剂的镇痛效果和耐受性测试，这些患者患有中度至重度术后和创伤后疼痛。舒洛芬滴剂给药7天，剂量为每日3次或4次，每次33滴（相当于200毫克舒洛芬）。在治疗前以及治疗2天、4天和7天后记录疼痛强度；在第2天、第4天和第7天评估疼痛缓解情况。在试验结束时，由研究者和患者对有效性和耐受性进行总体评估。在7天的治疗期内，疼痛强度从最初的重度降至轻度。治疗第2天后，92%的受试者疼痛得到缓解，第4天后为98%，第7天后为100%。研究者和患者对治疗效果的最终评估表明，86%的患者有良好的镇痛活性，84%的患者有非常好的镇痛效果。分别有12%和14%的患者效果中等。研究者和患者认为，82%的病例中舒洛芬滴剂的耐受性良好至非常好，16%的病例为中等，1例患者耐受性差。
