Malla RamaRao, Pappu Lalitha, Amajala Krishna Chaitanya, Kamal Mohammad Amjad
Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam 530045, Andhra Pradesh, India.
Department of Biochemistry and Bioinformatics, GIS, GITAM (Deemed to be University), Visakhapatnam 530045, Andhra Pradesh, India.
Curr Med Chem. 2022;29(40):6197-6216. doi: 10.2174/0929867329666220324143215.
Ample data pertaining to the use of MDSCs have been documented. However, the potency of natural products in targeting MDSCs in the light of the tumor immune microenvironment (TME) has not been discussed vividly. The current review is an amalgamation of the documented literature pertaining to the effectiveness of various natural products supported by in silico experimental data. The combination of bioinformatics to wet bench experimentation with natural products against cancer specifically targeting MDSCs can be a promising approach to mitigate cancer.
关于髓源性抑制细胞（MDSCs）使用的大量数据已有记录。然而，天然产物在肿瘤免疫微环境（TME）背景下靶向MDSCs的效力尚未得到充分讨论。本综述整合了已发表的文献以及计算机实验数据所支持的各种天然产物的有效性。将生物信息学与针对癌症的天然产物湿实验台实验相结合，特别是靶向MDSCs，可能是一种有前景的抗癌方法。
