喷布洛尔与普萘洛尔对肾功能受损高血压患者肾小球滤过率影响的比较。
Comparison of the effects of penbutolol and propranolol on glomerular filtration rate in hypertensive patients with impaired renal function.
作者信息
van der Meulen J, Reijn E, Heidendal G A, Oe P L, Donker A J
出版信息
Br J Clin Pharmacol. 1986 Oct;22(4):469-74. doi: 10.1111/j.1365-2125.1986.tb02919.x.
Abstract
Penbutolol and propranolol were administered orally in a dosage of 40 mg once daily and 80 mg twice daily, respectively to 12 patients with hypertension and impaired renal function. Both drugs caused a significant decrease in mean arterial pressure and heart rate. Serum creatinine concentration increased significantly by 10% during therapy with propranolol without concomitant decrease in creatinine clearance. No such effect was seen with penbutolol. GFR measured with [125I]-iothalamate showed no significant changes with both drugs.
摘要
对12例高血压伴肾功能受损患者分别口服喷布洛尔和普萘洛尔，剂量分别为每日1次40毫克和每日2次80毫克。两种药物均使平均动脉压和心率显著降低。在使用普萘洛尔治疗期间，血清肌酐浓度显著升高了10%，而肌酐清除率并未随之降低。喷布洛尔未出现此类效应。用[125I] - 碘肽酸盐测定的肾小球滤过率在两种药物治疗时均未显示出显著变化。
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