慢性肾衰竭合并高血压患者使用β受体阻滞剂后肾功能恶化。
Deterioration in renal function after beta-blockade in patients with chronic renal failure and hypertension.
作者信息
Warren D J, Swainson C P, Wright N
出版信息
Br Med J. 1974 Apr 27;2(5912):193-4. doi: 10.1136/bmj.2.5912.193.
Abstract
Treatment of hypertension with beta-blocking agents in three patients with moderately severe chronic renal failure was followed by rapid deterioration of renal function. In two of the patients the need for maintenance haemodialysis was accelerated but renal function in the third reverted to pretreatment levels after the drug was stopped. These findings suggest that until more is known about the effects of beta-blocking drugs they should not be given to patients with moderately severe renal failure.
摘要
在三名中度严重慢性肾衰竭患者中使用β受体阻滞剂治疗高血压后，肾功能迅速恶化。其中两名患者维持性血液透析的需求加速，但第三名患者在停药后肾功能恢复到治疗前水平。这些发现表明，在对β受体阻滞剂的作用有更多了解之前，不应将其给予中度严重肾衰竭患者。
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