Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal; Amyris Bio Products Portugal Unipessoal Lda, Portugal.
Int J Biol Macromol. 2022 May 31;208:1116-1126. doi: 10.1016/j.ijbiomac.2022.03.094. Epub 2022 Mar 21.
Bioactive peptides become popular in several economic sectors over the years as they have demonstrated important biological benefits in digestive, immune, cardiovascular, and nervous human systems. Although many commercial peptides are chemically synthesized, they can also be obtained from natural protein sources such as spent brewer's yeast (Saccharomyces cerevisiae). The recovery of this fermentation by-product for production of functional ingredients is an important step in the increasingly demand to implement and promote a circular economy-based industry. Bioactive peptides can be found in protein-rich extracts produced from S. cerevisiae, and several studies have described their positive impact of human body. In this line, the present review highlights and discuss the reported biological properties of S. cerevisiae bioactive peptides in terms of antihypertensive, antioxidant and antimicrobial effects, although other bioactivities are also described. Concerning the growing interest in yeast protein-rich products by agri-food and cosmetic sectors, some of the products currently on the market are also pointed out and their potential source is discussed.
生物活性肽多年来在多个经济领域受到关注，因为它们在人类的消化系统、免疫系统、心血管系统和神经系统中表现出重要的生物学益处。虽然许多商业肽是通过化学合成的，但它们也可以从天然蛋白质来源获得，如废啤酒酵母（酿酒酵母）。从这种发酵副产物中回收用于生产功能性成分是在日益需要实施和促进基于循环经济的产业方面的重要步骤。生物活性肽可以在从酿酒酵母中产生的富含蛋白质的提取物中找到，并且已经有几项研究描述了它们对人体的积极影响。在这方面，本综述重点讨论和讨论了报道的酿酒酵母生物活性肽在抗高血压、抗氧化和抗菌作用方面的生物学特性，尽管也描述了其他生物活性。鉴于农业食品和化妆品行业对富含酵母蛋白质的产品的兴趣日益浓厚，本文还指出了目前市场上的一些产品，并讨论了它们的潜在来源。
