Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Neurosci Biobehav Rev. 2022 May;136:104628. doi: 10.1016/j.neubiorev.2022.104628. Epub 2022 Mar 22.
Understanding the neural basis of cognitive deficits, a key feature of Alzheimer's disease (AD), is imperative for achieving the therapy of the disease. Rhythmic oscillatory activities in neural systems are a fundamental mechanism for diverse brain functions, including cognition. In several neurological conditions like AD, aberrant neural oscillations have been shown to play a central role. Furthermore, manipulation of brain oscillations in animals has confirmed their impact on cognition and disease. In this article, we review the evidence from mouse models that shows how synchronized oscillatory activity is intricately linked to AD machinery. We primarily focus on recent reports showing abnormal oscillatory activities at theta and gamma frequencies in AD condition and their influence on cellular disturbances and cognitive impairments. A thorough comprehension of the role that neuronal oscillations play in AD pathology should pave the way to therapeutic interventions that can curb the disease.
了解阿尔茨海默病（AD）的关键特征——认知缺陷的神经基础，对于实现该疾病的治疗至关重要。神经系统中的节律性振荡活动是包括认知在内的多种大脑功能的基本机制。在 AD 等几种神经疾病中，异常的神经振荡被证明起着核心作用。此外，对动物脑振荡的操纵已证实其对认知和疾病的影响。在本文中，我们回顾了来自小鼠模型的证据，这些证据表明同步振荡活动与 AD 机制密切相关。我们主要关注最近的报告，这些报告显示 AD 状态下θ和γ频率的异常振荡活动及其对细胞紊乱和认知障碍的影响。深入了解神经元振荡在 AD 病理中的作用应该为治疗干预铺平道路，从而抑制疾病。
