Kavaliers M, Hirst M
Brain Res Bull. 1986 Sep;17(3):403-8. doi: 10.1016/0361-9230(86)90246-7.
The peptide FMRFamide (Phe-Met-Arg-Phe-NH2), which displays a broad phylogenetic distribution, is considered to have important regulatory influences on basic functions in invertebrates. Extensive FMRFamide-like immunoreactive neuropeptides have also been demonstrated in the mammalian central nervous system, suggesting a possible physiological role for these peptides in mammals. There is evidence that FMRFamide, and/or related neuropeptides, may modulate opioid-mediated responses. Intracerebroventricular (ICV) administrations of FMRFamide inhibit in a dose-dependent manner (0.01-10 micrograms) mu- (morphine) and kappa- (U-50,488H) opiate-induced feeding in the laboratory mouse. In deer mice, FMRFamide inhibits the display of exogenous opiate-induced components of natural feeding behavior, such as food hoarding and food ingestion. In addition, ICV administrations of FMRFamide also antagonize endogenous opioid-mediated, stress-induced feeding in mice. These observations suggest that FMRFamide, or FMRFamide-like peptides present in the mammalian brain, may have important roles in the control of opioid-mediated feeding.
肽FMRF酰胺（苯丙氨酸-甲硫氨酸-精氨酸-苯丙氨酸-NH2）具有广泛的系统发育分布，被认为对无脊椎动物的基本功能具有重要的调节作用。在哺乳动物中枢神经系统中也发现了大量类似FMRF酰胺的免疫反应性神经肽，这表明这些肽在哺乳动物中可能具有生理作用。有证据表明，FMRF酰胺和/或相关神经肽可能调节阿片类药物介导的反应。在实验室小鼠中，脑室内（ICV）注射FMRF酰胺以剂量依赖性方式（0.01-10微克）抑制μ-（吗啡）和κ-（U-50,488H）阿片类药物诱导的进食。在鹿鼠中，FMRF酰胺抑制外源性阿片类药物诱导的自然进食行为成分的表现，如食物储存和食物摄取。此外，脑室内注射FMRF酰胺还能拮抗小鼠内源性阿片类药物介导的应激诱导进食。这些观察结果表明，FMRF酰胺或哺乳动物脑中存在的类似FMRF酰胺的肽可能在控制阿片类药物介导的进食中起重要作用。
