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PLG and FMRFamide--endogenous peptides with marked inhibitory effects on opioid-induced feeding.

作者信息

Kavaliers M, Hirst M

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):709-12. doi: 10.1016/0278-5846(85)90045-4.

DOI:10.1016/0278-5846(85)90045-4
PMID:4089195
Abstract

Social conflict and defeat in mice leads to an activation of endogenous opiate systems and the display of marked feeding behavior. Intraperitoneal administrations of prolyl-leucyl-glycinamide (PLG 0.01-10 mg/kg) leads to a dose-dependent inhibition of defeat-induced feeding that is analogous to that obtained after treatment with either the endogenous peptide FMRFamide (Phe-Met-Arg-Phe-NH2), or the prototypic opiate antagonist, naloxone. These results suggest that PLG, and FMRFamide, or related small peptides may function as endogenous antagonists of opioid-induced feeding.

摘要

相似文献

1
PLG and FMRFamide--endogenous peptides with marked inhibitory effects on opioid-induced feeding.
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):709-12. doi: 10.1016/0278-5846(85)90045-4.
2
FMRFamide, a putative endogenous opiate antagonist: evidence from suppression of defeat-induced analgesia and feeding in mice.
Neuropeptides. 1985 Dec;6(6):485-94. doi: 10.1016/0143-4179(85)90110-6.
3
FMRFamide: an endogenous peptide with marked inhibitory effects on opioid-induced feeding behavior.FMRF酰胺：一种对阿片类药物诱导的摄食行为具有显著抑制作用的内源性肽。
Brain Res Bull. 1986 Sep;17(3):403-8. doi: 10.1016/0361-9230(86)90246-7.
4
Inhibitory influences of FMRFamide and PLG on stress-induced opioid analgesia and activity.
Brain Res. 1986 May 7;372(2):370-4. doi: 10.1016/0006-8993(86)91147-9.
5
Inhibitory influences of mammalian FMRFamide (Phe-Met-Arg-Phe-amide)-related peptides on nociception and morphine- and stress-induced analgesia in mice.
Neurosci Lett. 1990 Jul 31;115(2-3):307-12. doi: 10.1016/0304-3940(90)90473-m.
6
Inhibitory influences of FMRFamide on morphine- and deprivation-induced feeding.FMRF酰胺对吗啡和剥夺诱导进食的抑制作用。
Neuroendocrinology. 1985 Jun;40(6):533-5. doi: 10.1159/000124126.
7
Effects of mammalian FMRF-NH2-related peptides and IgG from antiserum against them on aggression and defeat-induced analgesia in mice.
Peptides. 1991 Mar-Apr;12(2):235-9. doi: 10.1016/0196-9781(91)90005-a.
8
FMRFamide suppresses kappa opiate induced feeding in the mouse.苯甲酰酪氨酰胺抑制小鼠体内κ阿片肽诱导的进食行为。
Peptides. 1985 Sep-Oct;6(5):847-9. doi: 10.1016/0196-9781(85)90312-2.
9
Inhibitory influences of MIF-1 (PLG) and Tyr-MIF-1 (YPLG) on aggression and defeat-induced analgesia in mice.
Peptides. 1986 Nov-Dec;7(6):1007-10. doi: 10.1016/0196-9781(86)90129-4.
10
The actions of FMRF-NH2 and FMRF-NH2 related peptides on mammals.
NIDA Res Monogr. 1990;105:243-9.

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