Influence of pH, inoculum and media on the in vitro bactericidal activity of fosfomycin trometamol, norfloxacin and cotrimoxazole.

An in vitro study was made of the bactericidal activity against Escherichia coli of fosfomycin trometamol, a new fosfomycin salt characterized by high bioavailability in relation to the pH, inoculum and culture medium, the latter being nutrient broth or human urine. Cotrimoxazole and norfloxacin were used for comparison. The results obtained show that both in nutrient broth and human urine, fosfomycin trometamol had higher bactericidal action than that of the other two antimicrobial agents.