Dubini F, Riviera L
Institute of Medical Microbiology, University of Milan, Italy.
Chemioterapia. 1988 Feb;7(1):15-9.
The urinary concentrations of fosfomycin trometamol, norfloxacin, pipemidic acid and cotrimoxazole were studied at various times after oral administration of drugs in healthy volunteers. Using the same urine, the bactericidal activity of four antimicrobial agents against Escherichia coli, Proteus mirabilis and Klebsiella pneumoniae in an in vitro model simulating the treatment of bacterial cystitis was also evaluated. The results obtained show that very high concentrations of the drugs were achieved in urine particularly after the oral administration of the fosfomycin trometamol. In the bladder model bactericidal activity of fosfomycin trometamol, norfloxacin and pipemidic acid were higher than that of cotrimoxazole; no resistant mutants to drugs were selected over a period of 24 h.
在健康志愿者口服药物后的不同时间，研究了磷霉素氨丁三醇、诺氟沙星、吡哌酸和复方新诺明的尿药浓度。使用相同的尿液，还在模拟细菌性膀胱炎治疗的体外模型中评估了四种抗菌药物对大肠杆菌、奇异变形杆菌和肺炎克雷伯菌的杀菌活性。获得的结果表明，尿液中药物浓度非常高，尤其是口服磷霉素氨丁三醇之后。在膀胱模型中，磷霉素氨丁三醇、诺氟沙星和吡哌酸的杀菌活性高于复方新诺明；在24小时内未筛选出对药物耐药的突变体。
