Carlone N A, Borsotto M, Cuffini A M, Savoia D
Eur Urol. 1987;13 Suppl 1:86-91. doi: 10.1159/000472869.
The effect of fosfomycin trometamol in comparison with that of norfloxacin and co-trimoxazole on the hemagglutination, yeast cell aggregation and adhesive properties of both gram-positive and gram-negative microorganisms was studied. The strains were isolated from the urine of patients with urinary tract infections, or from vaginal swabs. At sublethal concentrations (1/4 and 1/8 of the minimal inhibitory concentration), the ability of the bacteria to adhere to human uroepithelial cells was reduced by any of the 3 drugs assayed. The reduction corresponded to a decrease in the agglutinating activity of the gram-negative bacteria tested, such providing further evidence for the efficacy of the different chemoantibiotics. In particular, fosfomycin trometamol and norfloxacin proved to be more effective than co-trimoxazole in affecting the adhesive properties of all the strains employed.
研究了磷霉素氨丁三醇与诺氟沙星和复方新诺明相比，对革兰氏阳性和革兰氏阴性微生物的血凝、酵母细胞聚集及黏附特性的影响。这些菌株从尿路感染患者的尿液或阴道拭子中分离得到。在亚致死浓度（最低抑菌浓度的1/4和1/8）下，所检测的3种药物中的任何一种都能降低细菌黏附人尿道上皮细胞的能力。这种降低与所检测的革兰氏阴性菌凝集活性的下降相对应，从而为不同化学抗生素的疗效提供了进一步证据。特别是，磷霉素氨丁三醇和诺氟沙星在影响所有所用菌株的黏附特性方面比复方新诺明更有效。
