School of Chemistry, University of Bristol, Cantocks Close, Bristol, BS8 1TS, UK.
EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Rd, Edinburgh EH9 3FJ, UK.
Analyst. 2022 Apr 11;147(8):1702-1708. doi: 10.1039/d2an00134a.
We demonstrate an extension to the SHARPER (Sensitive Homogenous and Refocussed Peaks in Real Time) NMR experiment which allows more than one signal to be monitored simultaneously, while still giving ultra-sharp, homo- and hetero-decoupled NMR signals. This is especially valuable in situations where magnetic field inhomogeneity would normally make NMR a problematic tool, for example when gas evolution is occurring during reaction monitoring. The originally reported SHARPER experiment only works for a single, on-resonance NMR signal, but here we demonstrate the Multiple Resonance SHARPER approach can be developed, which in principle can acquire multiple on-/off-resonance signals simultaneously while retaining the desirable properties of the parent sequence. In practice, the case of two resonances, those of a reactant and a product, will most of the time be considered for MR-SHARPER, as illustrated here.
我们展示了 SHARPER（实时敏感均匀和重聚焦峰）NMR 实验的扩展，该实验允许同时监测多个信号，同时仍能提供超尖锐、同核和异核去耦的 NMR 信号。在磁场不均匀通常会使 NMR 成为一个有问题的工具的情况下，例如在反应监测过程中发生气体逸出时，这尤其有价值。最初报道的 SHARPER 实验仅适用于单个、共振 NMR 信号，但在这里我们展示了可以开发多共振 SHARPER 方法，该方法原则上可以同时获取多个共振/非共振信号，同时保留原始序列的理想特性。在实践中，对于 MR-SHARPER，通常会考虑两种共振的情况，即反应物和产物的共振，如这里所示。
