Möst J, Wick G
Clin Immunol Immunopathol. 1986 Nov;41(2):175-83. doi: 10.1016/0090-1229(86)90101-7.
Surgical specimens from patients with Hashimoto thyroiditis (HT) or colloid goiter (CG) were analyzed using an immunofluorescence double staining technique to characterize the infiltrating mononuclear cells (MNC) and to determine the possible expression of HLA-DR antigens by these cells. In HT the majority of infiltrating MNC were T cells. In the interstitium T cells with helper/inducer phenotype (Leu 3a+) were more abundant than those with suppressor/cytotoxic phenotype (OKT8+) and approximately 10-25% of all T cells expressed HLA-DR. Among the cells in peripolesis [i.e., protruding between thyroid epithelial cells (TEC)] OKT8+ cells were observed more frequently than Leu 3a+ cells, expression of DR antigens being 7 and 12%, respectively. The occurrence of Leu 3a+ cells in peripolesis is in marked contrast to the findings in colloid goiter where the intraepithelial population of MNC is almost exclusively composed of OKT8+ cells. The various ways in which the peripoletic Leu 3a+ cells could contribute to the special pathogenesis of HT are discussed.
采用免疫荧光双染色技术对桥本甲状腺炎（HT）或胶样甲状腺肿（CG）患者的手术标本进行分析，以鉴定浸润的单核细胞（MNC），并确定这些细胞是否可能表达HLA - DR抗原。在HT中，大多数浸润的MNC是T细胞。在间质中，具有辅助/诱导表型（Leu 3a +）的T细胞比具有抑制/细胞毒性表型（OKT8 +）的T细胞更丰富，并且所有T细胞中约10 - 25%表达HLA - DR。在周皮细胞（即甲状腺上皮细胞（TEC）之间突出的细胞）中，观察到OKT8 +细胞比Leu 3a +细胞更频繁，DR抗原的表达分别为7%和12%。周皮细胞中Leu 3a +细胞的出现与胶样甲状腺肿的发现形成明显对比，在胶样甲状腺肿中，上皮内的MNC几乎完全由OKT8 +细胞组成。本文讨论了周皮Leu 3a +细胞可能参与HT特殊发病机制的各种方式。
