青少年自身免疫性甲状腺炎中的甲状腺浸润淋巴细胞、甲状腺功能及人类白细胞抗原-DR

Thyroid-infiltrating lymphocytes, thyroid function, and HLA-DR in juvenile autoimmune thyroiditis.

作者信息

Mäenpää J, Lautenschlager I, Nyberg M, Koskimies S, Kontiainen S

机构信息

Department of Pediatrics, Aurora Hospital, Helsinki, Finland.

出版信息

Acta Endocrinol (Copenh). 1989 Oct;121(4):573-7. doi: 10.1530/acta.0.1210573.

DOI:10.1530/acta.0.1210573

PMID:2678872

Abstract

Eighteen patients with juvenile autoimmune thyroiditis were studied. At diagnosis 8 (44%) of the patients were euthyroid and 10 hypothyroid, whereas at the end of 6 to 12 months follow-up, 12 (66%) were euthyroid and 6 hypothyroid. All the patients were HLA-typed. The frequency of HLA-DR4 was increased in the patients when compared with the normal population, 63 vs 28% (p less than 0.01). An analysis of thyroid-infiltrating mononuclear cells revealed that the majority of the thyroid-infiltrating lymphocytes were T cells. More T lymphocytes and fewer B lymphocytes and HLA class II positive lymphocytes were found among the thyroid-infiltrating mononuclear cells in euthyroid than hypothyroid patients. The numbers of thyroid-infiltrating B lymphocytes correlated with the levels of thyroid microsomal antibodies. No correlation was found between thyroid function and thyroid antibodies.

摘要

对18例青少年自身免疫性甲状腺炎患者进行了研究。诊断时，8例（44%）患者甲状腺功能正常，10例甲状腺功能减退；而在6至12个月的随访结束时，12例（66%）甲状腺功能正常，6例甲状腺功能减退。所有患者均进行了HLA分型。与正常人群相比，患者中HLA - DR4的频率增加，分别为63%和28%（p<0.01）。对甲状腺浸润性单核细胞的分析显示，大多数甲状腺浸润淋巴细胞为T细胞。与甲状腺功能减退患者相比，甲状腺功能正常患者的甲状腺浸润单核细胞中T淋巴细胞更多，B淋巴细胞和HLA II类阳性淋巴细胞更少。甲状腺浸润B淋巴细胞的数量与甲状腺微粒体抗体水平相关。未发现甲状腺功能与甲状腺抗体之间存在相关性。