Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
Key Laboratory of Functional Molecules Analysis and Biotransformation of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, P. R. China.
Chem Biodivers. 2022 May;19(5):e202200064. doi: 10.1002/cbdv.202200064. Epub 2022 Mar 25.
Actinomycetes have being regarded as a treasure reservoir of various bioactive secondary metabolites and devoted many antibiotics in clinicals. Amycolatopsis sp. YNNP 00208 was isolated from a soil sample collected in Gaoligong Mountain area, Yunnan Province, China. Chemical investigation of its fermentation broth led to a new amide, baoshanmycin (1), and a new furanone derivative, 3-(1,3-dihydroxybutyl)-4-methylfuran-2(H)-one (2), together with eight known compounds, including two amides (3-4), four cyclic dipeptides (5-8), and two deoxyribonucleosides (9-10). Their structures were established on basis of the 1D- and 2D-NMR spectroscopic data, along with the HR-ESI-MS experiments. Baoshanmycin (1) showed moderate antimicrobial activities against Candida albicans, and weak activities against Staphylococcus aureus, multi-drug resistant Staphylococcus aureus, Bacillus subtilis, Listeria monocytogenes, fluconazole-resistant Candida albicans. Baoshanmycin (1) presented strong antioxidant activity and moderate anti-acetylcholinesterase activity. The other compound 3-(1,3-dihydroxybutyl)-4-methylfuran-2(H)-one (2) and the known compounds (3-10) showed moderate antioxidant activity.
放线菌被视为各种生物活性次级代谢产物的宝库，为临床提供了许多抗生素。Amycolatopsis sp. YNNP 00208 是从中国云南省高黎贡山地区采集的土壤样本中分离出来的。对其发酵液的化学研究导致了一种新的酰胺，保山霉素（1）和一种新的呋喃酮衍生物，3-(1,3-二羟基丁基)-4-甲基-2(H)-呋喃酮（2），以及其他 8 种已知化合物，包括两种酰胺（3-4），四种环状二肽（5-8）和两种脱氧核苷（9-10）。它们的结构是基于 1D-和 2D-NMR 光谱数据以及 HR-ESI-MS 实验确定的。保山霉素（1）对白色念珠菌具有中等的抗菌活性，对金黄色葡萄球菌、耐多药金黄色葡萄球菌、枯草芽孢杆菌、李斯特菌单核细胞增生症、氟康唑耐药白色念珠菌具有较弱的活性。保山霉素（1）具有很强的抗氧化活性和中等的抗乙酰胆碱酯酶活性。其他化合物 3-(1,3-二羟基丁基)-4-甲基-2(H)-呋喃酮（2）和已知化合物（3-10）具有中等的抗氧化活性。
