来自链霉菌属sp. MCC0218的恩塞拉霉素A-C，呋喃萘醌类：分离、结构解析及抗菌活性
Enceleamycins A-C, Furo-Naphthoquinones from sp. MCC0218: Isolation, Structure Elucidation, and Antimicrobial Activity.
作者信息
Khan Abujunaid, Said Madhukar S, Borade Balasaheb R, Gonnade Rajesh, Barvkar Vitthal, Kontham Ravindar, Dastager Syed G
机构信息
NCIM-Resource Center, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India.
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India.
出版信息
J Nat Prod. 2022 May 27;85(5):1267-1273. doi: 10.1021/acs.jnatprod.1c01160. Epub 2022 Apr 29.
Three novel furo-naphthoquinones, enceleamycins A-C (-), and a new -hydroxypyrazinone acid () were identified from the strain sp. MCC 0218, isolated from a soil sample collected from the Western Ghats of India. Their chemical structure and absolute and relative configurations were established by 1D and 2D NMR spectroscopy, single-crystal X-ray crystallography, and high-resolution mass spectrometry. Compounds and were active against methicillin-susceptible and -resistant with MIC values of 2-16 μg/mL.
从印度西高止山脉采集的土壤样本中分离出的菌株sp. MCC 0218中，鉴定出了三种新型呋喃萘醌类化合物，即恩塞霉素A-C（-），以及一种新的羟基吡嗪酮酸（）。通过一维和二维核磁共振光谱、单晶X射线晶体学和高分辨率质谱确定了它们的化学结构以及绝对和相对构型。化合物和对甲氧西林敏感和耐药的均有活性，最低抑菌浓度值为2-16μg/mL。
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