Scleral Lens Thickness and Corneal Edema Under Open Eye Conditions.

PURPOSE

To examine the relationship between lens thickness and central corneal edema during short-term open-eye scleral lens wear, and to compare these empirical edema measurements with theoretical modelling.

METHODS

Nine participants (mean age 30 years) with normal corneas wore scleral lenses {Dk 141×10-11 cm3 O2 [cm]/([sec] [cm2] [mm Hg])} under open-eye conditions on separate days with nominal center thicknesses of 150, 300, 600, and 1,200 μm. Epithelial, stromal, and total corneal edema were measured using high-resolution optical coherence tomography immediately after lens application and after 90 min of wear, before lens removal.

RESULTS

Central corneal edema was primarily stromal in nature and increased with increasing central lens thickness. The mean±standard error total corneal edema was 1.14±0.22%, 1.36±0.26%, 1.74±0.30%, and 2.13±0.24% for the 150, 300, 600, and 1,200 μm lenses, respectively. A significant difference in stromal and total corneal edema was observed between the 1,200 and 150 μm thickness lenses only (both P<0.05). Theoretical modelling overestimated the magnitude of central corneal edema and the influence of central lens thickness when the scleral lens Dk/t was less than 20.

CONCLUSION

Scleral lens-induced central corneal edema during short-term open-eye lens wear increases with increasing central lens thickness. Theoretical models overestimated the effect of increasing scleral lens thickness upon central corneal edema for higher lens thickness values (lens Dk/t<20) when controlling for initial central fluid reservoir thickness.