Angra Vani, Sehgal Rutika, Gupta Reena
Department of Biotechnology, Himachal Pradesh University, Summerhill, Shimla, 171005, India.
Microb Ecol. 2023 Feb;85(2):572-585. doi: 10.1007/s00248-022-01995-w. Epub 2022 Mar 25.
Along with the wide applications of conventional plastics, they have a large number of disadvantages like their non-biodegradable nature, dependency on fossil fuels and the release of large amounts of toxic materials in the environment. Therefore, to resolve these problems, a number of bioplastics are studied, out of which polyhydroxyalkanoates are considered as the best alternatives. Polyhydroxyalkanoates (PHAs) are produced by microorganisms as intracellular granules during stressful conditions. Though a wide range of organisms can naturally produce PHAs, only a few of them can be used for commercial production. Therefore, more diverse organisms that accumulate a considerable amount of PHAs and also reduce the production cost need to be exploited. Transgenic plants, recombinant bacteria, algae and extremophiles are some diverse organisms that produce a high amount of PHAs at a low cost. So, if potential organisms are used for PHA production, bioplastics will be able to completely replace petroleum-based polymers. Therefore, our review mainly focuses on production of PHAs using potential organisms so that amount of PHAs produced is high and cost-effective which would further help in the commercialization of PHAs.
随着传统塑料的广泛应用,它们存在大量缺点,如不可生物降解、依赖化石燃料以及在环境中释放大量有毒物质。因此,为了解决这些问题,人们研究了多种生物塑料,其中聚羟基脂肪酸酯被认为是最佳替代品。聚羟基脂肪酸酯(PHA)是微生物在应激条件下作为细胞内颗粒产生的。虽然有多种生物能够自然产生PHA,但只有少数几种可用于商业生产。因此,需要开发更多能积累大量PHA且能降低生产成本的不同生物。转基因植物、重组细菌、藻类和极端微生物是一些能低成本大量生产PHA的不同生物。所以,如果将潜在生物用于PHA生产,生物塑料将能够完全替代石油基聚合物。因此,我们的综述主要关注利用潜在生物生产PHA,以使PHA的产量高且具有成本效益,这将进一步有助于PHA的商业化。