固有淋巴细胞招募T细胞以增强对肿瘤的攻击。
Innate lymphoid cells recruit T cells to turn up the heat on tumors.
作者信息
Mills Kingston H G
机构信息
School of Biochemistry and Immunology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland.
出版信息
Cancer Cell. 2022 Apr 11;40(4):362-364. doi: 10.1016/j.ccell.2022.03.002. Epub 2022 Mar 24.
PMID:35334205
Abstract
In a recent publication in Nature Immunology, Bruchard et al. report that type 3 innate lymphoid cells, activated and recruited by cisplatin-induced chemokine ligand 20 (CCL20) and interleukin-1 beta (IL-1β), promote CD4 and CD8 T cell infiltration into murine tumors. This turns "cold" tumors "hot", thereby enhancing responsiveness to immune checkpoint inhibitors.
摘要
在最近发表于《自然免疫学》的一篇论文中，布鲁查德等人报告称，顺铂诱导的趋化因子配体20（CCL20）和白细胞介素-1β（IL-1β）激活并招募的3型天然淋巴细胞，可促进CD4和CD8 T细胞浸润到小鼠肿瘤中。这使得“冷”肿瘤变“热”，从而增强对免疫检查点抑制剂的反应性。
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