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自动分割正常和病变的冠状动脉 - ASOCA 挑战赛。

Automated segmentation of normal and diseased coronary arteries - The ASOCA challenge.

机构信息

School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, Australia.

Prince of Wales Clinical School of Medicine, UNSW Sydney, Australia; Department of Cardiology, Prince of Wales Hospital, Sydney, Australia.

出版信息

Comput Med Imaging Graph. 2022 Apr;97:102049. doi: 10.1016/j.compmedimag.2022.102049. Epub 2022 Feb 18.

Abstract

Cardiovascular disease is a major cause of death worldwide. Computed Tomography Coronary Angiography (CTCA) is a non-invasive method used to evaluate coronary artery disease, as well as evaluating and reconstructing heart and coronary vessel structures. Reconstructed models have a wide array of for educational, training and research applications such as the study of diseased and non-diseased coronary anatomy, machine learning based disease risk prediction and in-silico and in-vitro testing of medical devices. However, coronary arteries are difficult to image due to their small size, location, and movement, causing poor resolution and artefacts. Segmentation of coronary arteries has traditionally focused on semi-automatic methods where a human expert guides the algorithm and corrects errors, which severely limits large-scale applications and integration within clinical systems. International challenges aiming to overcome this barrier have focussed on specific tasks such as centreline extraction, stenosis quantification, and segmentation of specific artery segments only. Here we present the results of the first challenge to develop fully automatic segmentation methods of full coronary artery trees and establish the first large standardized dataset of normal and diseased arteries. This forms a new automated segmentation benchmark allowing the automated processing of CTCAs directly relevant for large-scale and personalized clinical applications.

摘要

心血管疾病是全球范围内主要的死亡原因。计算机断层扫描冠状动脉造影(CTCA)是一种用于评估冠状动脉疾病的非侵入性方法,同时还可以评估和重建心脏和冠状动脉结构。重建模型在教育、培训和研究中有广泛的应用,例如研究患病和非患病的冠状动脉解剖结构、基于机器学习的疾病风险预测以及医疗器械的计算机模拟和体外测试。然而,由于冠状动脉的体积小、位置和运动方式,导致其成像效果不佳,存在较差的分辨率和伪影。冠状动脉的分割传统上侧重于半自动方法,即人类专家指导算法并纠正错误,但这严重限制了大规模应用和在临床系统中的集成。旨在克服这一障碍的国际挑战集中在特定任务上,如中心线提取、狭窄量化和特定动脉段的分割。在这里,我们展示了首次开发完整冠状动脉树全自动分割方法的挑战结果,并建立了第一个正常和患病动脉的大型标准化数据集。这形成了一个新的自动化分割基准,允许直接对大规模和个性化的临床应用中的 CTCAs 进行自动处理。

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