Skolkovo Institute of Science and Technology, 30, bld. 1 Bolshoy Boulevard, Moscow 121205, Russia.
World-class research center, Advanced Digital Technologies, Saint Petersburg State Marine Technical University, Lotsmanskaya street, 3, Saint-Peterburg, 190121, Russia.
Biomed Mater. 2022 Apr 12;17(3). doi: 10.1088/1748-605X/ac6124.
Due to many negative and undesirable side effects from the use of permanent implants, the development of temporary implants based on biocompatible and biodegradable materials is a promising area of modern medicine. In the presented study, we have investigated complex-shaped iron-silicon (Fe-Si) scaffolds that can be used as potential biodegradable framework structures for solid implants for bone grafting. Since iron and silicon are biocompatible materials, and their alloy should also have biocompatibility. It has been demonstrated that cells, mesenchymal stromal cells derived from the human umbilical cord (UC-MSC) and 3T3, were attached to, spread, and proliferated on the Fe-Si scaffolds' surface. Most of UC-MSC and 3T3 remained viable, only single dead cells were observed. According to the results of biological testing, the scaffolds have shown that deposition of calcium phosphate particles occurs on day one in the scaffold at the defect site that can be used as a primary marker of osteodifferentiation. These results demonstrate that the 3D-printed porous iron-silicon (Fe-Si) alloy scaffolds are promising structures for bone grafting and regeneration.
由于永久性植入物的使用会带来许多负面和不良的副作用，因此基于生物相容性和可生物降解材料的临时植入物的开发是现代医学的一个有前途的领域。在本研究中，我们研究了复杂形状的铁-硅（Fe-Si）支架，这些支架可用作用于骨移植的固体植入物的潜在可生物降解框架结构。由于铁和硅是生物相容性材料，它们的合金也应该具有生物相容性。已经证明，细胞，源自人脐带（UC-MSC）和 3T3 的间充质基质细胞，附着在 Fe-Si 支架表面上、扩散并增殖。大多数 UC-MSC 和 3T3 保持存活，仅观察到单个死细胞。根据生物测试的结果，支架已经显示出在缺陷部位的支架上的第一天就发生了磷酸钙颗粒的沉积，这可以用作成骨分化的主要标记物。这些结果表明，3D 打印多孔铁-硅（Fe-Si）合金支架是用于骨移植和再生的有前途的结构。
