Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Medicina (Kaunas). 2022 Feb 25;58(3):350. doi: 10.3390/medicina58030350.
Background and Objectives: The aim of this study was to evaluate short-term continuous positive air pressure (CPAP) treatment for health-related quality of life (HRQL) in patients with obstructive sleep apnea. Materials and Methods: Our subjects were 18−65 years old, diagnosed with moderate-to-severe obstructive sleep apnea and treated with CPAP between January 2020 and June 2021 in Hospital of Lithuanian University of Health Sciences Kaunas clinics. All the patients completed the Epworth Sleepiness Scale (ESS), the 36-Item Short Form Health Survey (SF-36), the and Pittsburgh Sleep Quality Index (PSQI) before and after 3 months of treatment. Polysomnography was also repeated. Statistical analyses were performed using SPSS 27.0 software. The value of p < 0.05 was considered as statistically significant. Results: The active-treatment group comprised 17 subjects with a mean age of 51.9 ± 8.9 years. The total SF-36 questionnaire score improved from 499.8 ± 122.3 to 589.6 ± 124.7 (p = 0.012). The SF-36 role limitations due to emotional problems (p = 0.021), energy (fatigue) (p = 0.035), and general health (p = 0.042) domains score significantly improved after CPAP treatment for 3 months. The PSQI mean score at baseline was 12.6 ± 2.9 and in the post-treatment group, it was −5.5 ± 2.3 (p = 0.001). The ESS also changed significantly from a pretreatment mean score of 10.9 ± 5.7 to −5.3 ± 3.2 (p = 0.002) after 3 months. Conclusions: Improvement in HRQL is seen even after a short treatment period with CPAP. Questionnaires are a good tool to evaluate CPAP treatment efficacy.
本研究旨在评估短期持续气道正压通气（CPAP）治疗对阻塞性睡眠呼吸暂停患者健康相关生活质量（HRQL）的影响。材料与方法：我们的研究对象为 2020 年 1 月至 2021 年 6 月在立陶宛健康科学大学考纳斯附属医院诊所接受 CPAP 治疗的 18-65 岁、中重度阻塞性睡眠呼吸暂停患者。所有患者在治疗前和治疗 3 个月后均完成了 Epworth 嗜睡量表（ESS）、36 项简短健康调查问卷（SF-36）和匹兹堡睡眠质量指数（PSQI）的评估。同时还重复了多导睡眠图检查。统计分析使用 SPSS 27.0 软件进行。p 值＜0.05 被认为具有统计学意义。结果：在积极治疗组中，有 17 例患者，平均年龄为 51.9±8.9 岁。SF-36 总问卷评分从 499.8±122.3 提高到 589.6±124.7（p=0.012）。CPAP 治疗 3 个月后，SF-36 中角色限制因情绪问题（p=0.021）、能量（疲劳）（p=0.035）和一般健康（p=0.042）的评分显著改善。基线时 PSQI 的平均得分为 12.6±2.9，治疗组的 PSQI 平均得分为-5.5±2.3（p=0.001）。ESS 也从治疗前的 10.9±5.7 分显著下降至 3 个月后的-5.3±3.2 分（p=0.002）。结论：即使是短期 CPAP 治疗也能改善 HRQL。问卷是评估 CPAP 治疗效果的良好工具。
