二甲双胍：用途和效果的性别差异——叙述性综述。
Metformin: Sex/Gender Differences in Its Uses and Effects-Narrative Review.
机构信息
Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, GR-11521 Athens, Greece.
Department of Health Promotion Sciences, Maternal and Infantile Care, Internal Medicine and Medical Specialties (Promise), School of Medicine, University of Palermo, Via del Vespro, 141, 90127 Palermo, Italy.
出版信息
Medicina (Kaunas). 2022 Mar 16;58(3):430. doi: 10.3390/medicina58030430.
Metformin (MTF) occupies a major and fundamental position in the therapeutic management of type 2 diabetes mellitus (T2DM). Gender differences in some effects and actions of MTF have been reported. Women are usually prescribed lower MTF doses compared to men and report more gastrointestinal side effects. The incidence of cardiovascular events in women on MTF has been found to be lower to that of men on MTF. Despite some promising results with MTF regarding pregnancy rates in women with PCOS, the management of gestational diabetes, cancer prevention or adjunctive cancer treatment and COVID-19, most robust meta-analyses have yet to confirm such beneficial effects.
二甲双胍（MTF）在 2 型糖尿病（T2DM）的治疗管理中占据着主要和基础地位。据报道，MTF 在一些效果和作用上存在性别差异。女性通常比男性服用的 MTF 剂量更低，并且报告的胃肠道副作用更多。服用 MTF 的女性发生心血管事件的发生率低于服用 MTF 的男性。尽管 MTF 在多囊卵巢综合征（PCOS）女性的妊娠率、妊娠糖尿病的管理、癌症预防或辅助癌症治疗以及 COVID-19 方面取得了一些有希望的结果，但大多数强有力的荟萃分析尚未证实这些有益效果。
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