Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, China.
College of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun 558000, China.
Nutrients. 2022 Mar 8;14(6):1128. doi: 10.3390/nu14061128.
It is well known that obesity induced by high-fat diet (HFD) poses a serious threat to people's health. Fuzhuan brick tea, one of the most popular beverages, is reported to possess a significant effect on regulating lipid metabolism, attributed to its many bioactive ingredients. However, the efficacy and mechanism of compound Fuzhuan brick tea (CFBT) made from Fuzhuan brick tea and other six Chinese herbal medicines are still not well defined.
Sixty mice were divided into six groups: normal control group (CK), high-fat model group (NK), positive control group with anti-hyperlipidemic drug (YK), CFBT at low-(FL), medium-(FM) and high-(FH) dosage. Intervening for 30 days, conventional indexes analysis combined with metabolomics were performed to evaluate the changes in biochemical indexes and liver metabolic profiles in mice submitted to HFD.
CFBT treatment was able to ameliorate obesity, serum biochemical parameters, antioxidant activity and hepatic steatosis. In addition, significant alterations in the liver tissue metabolic profiles were observed, with most of these associated with inflammation, glucose and lipid metabolism.
This study provides evidence that consumption of CFBT is capable of preventing dyslipidemia, reducing weight gain, restoring liver injury, as well as improving metabolic disorders.
众所周知，高脂肪饮食（HFD）引起的肥胖对人们的健康构成严重威胁。茯砖茶是最受欢迎的饮料之一，据报道其对调节脂质代谢有显著作用，这归因于其多种生物活性成分。然而，由茯砖茶和其他六种中草药制成的复方茯砖茶（CFBT）的功效和机制仍不明确。
将 60 只小鼠分为 6 组：正常对照组（CK）、高脂模型组（NK）、降脂药阳性对照组（YK）、CFBT 低剂量组（FL）、中剂量组（FM）和高剂量组（FH）。干预 30 天后，采用常规指标分析结合代谢组学方法评价 HFD 诱导的小鼠生化指标和肝脏代谢谱的变化。
CFBT 治疗可改善肥胖、血清生化参数、抗氧化活性和肝脂肪变性。此外，还观察到肝组织代谢谱发生了显著变化，其中大多数与炎症、糖和脂质代谢有关。
本研究表明，CFBT 的摄入可预防血脂异常、减轻体重增加、恢复肝损伤以及改善代谢紊乱。
