Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Nutrients. 2022 Mar 9;14(6):1157. doi: 10.3390/nu14061157.
Partially hydrolyzed guar gum (PHGG) is a soluble dietary fiber derived through controlled enzymatic hydrolysis of guar gum, a highly viscous galactomannan derived from the seeds of . Here, we examined the therapeutic potential of dietary supplementation with PHGG against sarcopenic obesity using Db/Db mice. Db/Db mice fed a normal diet alone or a fiber-free diet, or supplemented with a diet containing PHGG (5%), were examined. PHGG increased grip strength and the weight of skeletal muscles. PHGG increased the short-chain fatty acids (SCFAs) concentration in feces and sera. Concerning innate immunity, PHGG decreased the ratio of inflammatory cells, while increasing the ratio of anti-inflammatory cells in the small intestine. The present study demonstrated the preventive effect of PHGG on sarcopenic obesity. Changes in nutrient absorption might be involved through the promotion of an anti-inflammatory shift of innate immunity in the intestine accompanied by an increase in SCFA production by PHGG.
部分水解瓜尔胶（PHGG）是一种可溶性膳食纤维，通过对瓜尔胶的可控酶解得到，瓜尔胶是一种高度粘稠的半乳甘露聚糖，来源于. 在这里，我们使用 Db/Db 小鼠研究了通过饮食补充 PHGG 治疗肌少症性肥胖的潜力。检查了单独喂食正常饮食、不含纤维饮食或补充含 PHGG（5%）饮食的 Db/Db 小鼠。PHGG 增加了握力和骨骼肌的重量。PHGG 增加了粪便和血清中的短链脂肪酸（SCFA）浓度。关于先天免疫，PHGG 降低了炎症细胞的比例，同时增加了小肠中抗炎细胞的比例。本研究证明了 PHGG 对肌少症性肥胖的预防作用。通过促进肠道先天免疫的抗炎转变，同时增加 PHGG 产生的短链脂肪酸（SCFA），可能会改变营养吸收。
