Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Agilent Technologies, Chromatography Mass Spectrometry Sales Department, Life Science and Applied Markets Group, Tokyo 192-8510, Japan.
Endocr J. 2021 Apr 28;68(4):421-428. doi: 10.1507/endocrj.EJ20-0564. Epub 2020 Dec 22.
Diabetic retinopathy (DR), one of the major complications of diabetes, can cause blindness and reduce quality of life. Dyslipidemia is reported to be associated with DR, whereas arachidonic acid may have a protective effect against DR. We aimed to investigate the association of circulating n-3 and n-6 polyunsaturated fatty acids (PUFAs) with DR. In this cross-sectional study, 190 Japanese patients with type 2 diabetes were classified as no diabetic retinopathy (NDR), simple diabetic retinopathy (SDR), or proliferative diabetic retinopathy (PDR) including pre-proliferative diabetic retinopathy. Circulating fatty acids (FAs) were measured by gas chromatograph-mass spectrometry. Logistic regression analysis was performed to investigate the association between the levels of FAs and the presence of DR. The average age, body mass index and the duration of diabetes were 62.7 ± 12.1 years, 25.0 ± 4.5 kg/m, and 9.8 ± 8.7 years, respectively. Twenty-seven patients were diagnosed with DR. Circulating levels of dihomo-gamma-linolenic acid (DGLA) in the NDR (n = 163), SDR (n = 13) and PDR (n = 14) groups were 28.3 ± 11.0 μg/mL, 24.4 ± 9.7 μg/mL, and 21.8 ± 6.2 μg/mL, respectively (p = 0.032). The logarithm of circulating DGLA levels was associated with the presence of DR after adjusting for covariates (OR of 1-unit increment: 0.79, 95% CI: 0.62-1.00, p = 0.049). Circulating DGLA was negatively associated with the presence of DR.
糖尿病性视网膜病变（DR）是糖尿病的主要并发症之一，可导致失明并降低生活质量。血脂异常与 DR 有关，而花生四烯酸可能对 DR 有保护作用。我们旨在研究循环 n-3 和 n-6 多不饱和脂肪酸（PUFAs）与 DR 的关系。在这项横断面研究中，190 名日本 2 型糖尿病患者分为无糖尿病性视网膜病变（NDR）、单纯糖尿病性视网膜病变（SDR）或增生性糖尿病性视网膜病变（PDR），包括前增生性糖尿病性视网膜病变。通过气相色谱-质谱法测量循环脂肪酸（FA）。进行逻辑回归分析以研究 FA 水平与 DR 存在之间的关系。平均年龄、体重指数和糖尿病病程分别为 62.7 ± 12.1 岁、25.0 ± 4.5 kg/m 和 9.8 ± 8.7 年。27 名患者被诊断为 DR。NDR（n = 163）、SDR（n = 13）和 PDR（n = 14）组的循环二高-γ-亚麻酸（DGLA）水平分别为 28.3 ± 11.0 μg/mL、24.4 ± 9.7 μg/mL 和 21.8 ± 6.2 μg/mL（p = 0.032）。在校正协变量后，循环 DGLA 水平的对数值与 DR 的存在相关（每单位增加的 OR：0.79，95%CI：0.62-1.00，p = 0.049）。循环 DGLA 与 DR 的存在呈负相关。
