Department of Research and Design, Bioflag Biotech Co., Ltd., Tainan 744, Taiwan.
Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333, Taiwan.
Nutrients. 2022 Mar 17;14(6):1270. doi: 10.3390/nu14061270.
Obesity is a worldwide health problem. Calorie-restricted diets constitute a common intervention for treating obesity. However, an improper calorie-restricted diet can lead to malnutrition, fatigue, poor concretion, muscle loss, and reduced exercise performance. Probiotics have been introduced as an alternative treatment for obesity. In the present study, we tested the weight loss and exercise performance enhancement effectiveness of probiotic strains of different origins, including four isolated from an Olympic weightlifting gold medalist ( subsp. OLP-01, PL-02, subsp. SA-03, and subsp. LY-66). A high-fat diet (HFD) was used to induce obesity in 16 groups of mice ( = 8/group). The mice were administered probiotic supplements at a dosage of 4.1 × 10 CFU/kg/day for 10 weeks. All probiotic supplementation groups showed a significant reduction in body weight and fat mass compared with the HFD group. TYCA06, CS-773, BLI-02, PL-02, bv-77, and OLP-01 were the most effective in facilitating weight loss and fat reduction, which may be due to fatty-acid absorbing activity. PL-02, LY-66, TYCA06, CS-773, and OLP-01 elevated the animals' grip strength and exhaustive running duration. PL-02, LY-66, and OLP-01 increased tissue glycogen (liver and muscle) levels and muscle capillary density and reduced blood lactate production levels after exercise. In conclusion, OLP-01, PL-02, LY-66, TYCA06, and CS-773 were highly effective in enhancing weight loss and exercise performance. This study should be repeated on humans in the future to further confirm the findings.
肥胖是一个全球性的健康问题。限制热量的饮食构成了治疗肥胖的常见干预措施。然而，不适当的热量限制饮食会导致营养不良、疲劳、身体虚弱、肌肉损失和运动表现下降。益生菌已被引入作为肥胖的替代治疗方法。在本研究中，我们测试了不同来源的益生菌菌株的减肥和增强运动表现的效果，包括从一位奥运举重金牌得主中分离出的四种（亚种 OLP-01、PL-02、亚种 SA-03 和亚种 LY-66）。高脂肪饮食（HFD）用于诱导 16 组小鼠肥胖（每组 8 只）。将益生菌补充剂以 4.1×10 CFU/kg/天的剂量给予小鼠，持续 10 周。与 HFD 组相比，所有益生菌补充组的体重和脂肪量均显著降低。TYCA06、CS-773、BLI-02、PL-02、bv-77 和 OLP-01 最有效地促进体重减轻和脂肪减少，这可能是由于脂肪酸吸收活性。PL-02、LY-66、TYCA06、CS-773 和 OLP-01 提高了动物的握力和力竭跑步时间。PL-02、LY-66 和 OLP-01 增加了组织糖原（肝脏和肌肉）水平和肌肉毛细血管密度，并降低了运动后的血乳酸生成水平。总之，OLP-01、PL-02、LY-66、TYCA06 和 CS-773 非常有效地增强了减肥和运动表现。未来应在人类中重复这项研究，以进一步证实这些发现。
